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Recovery After Stroke: Not So Proportional After All?

Hope, Thomas M.H., Friston, Karl J., Price, Cathy J., Leff, Alex P., Rotshtein, Pia, Bowman, Howard (2019) Recovery After Stroke: Not So Proportional After All? Brain, 142 (1). pp. 15-22. ISSN 0006-8950. E-ISSN 1460-2156. (doi:10.1093/brain/awy302) (KAR id:69746)

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The proportional recovery rule asserts that most stroke survivors recover a fixed proportion of lost function. To the extent that this is true, recovery from stroke can be predicted accurately from baseline measures of acute post-stroke impairment alone. Reports that baseline scores explain more

coefficients between baseline scores and recovery (outcome scores minus baseline scores). Using formal analyses and simulations, we show that these correlations will be extreme when outcomes are less variable than baselines, which they often will be in practice regardless of the real relationship between outcomes and baselines. We show that these effect sizes are likely to be over optimistic in every empirical study that we found, which reported enough information for us to make the judgement, and argue that the same is likely to be true in other studies as well. The implication is that recovery after stroke may not be as proportional as recent studies suggest.

Item Type: Article
DOI/Identification number: 10.1093/brain/awy302
Uncontrolled keywords: proportional recovery, stroke, methods, statistics
Divisions: Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Depositing User: Howard Bowman
Date Deposited: 22 Oct 2018 14:47 UTC
Last Modified: 16 Feb 2021 13:58 UTC
Resource URI: (The current URI for this page, for reference purposes)
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