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Reconstruction of avian ancestral karyotypes reveals differences in the evolutionary history of macro- and microchromosomes

Damas, Joana, Kim, Jaebum, Farré, Marta, Griffin, Darren K., Larkin, Denis M. (2018) Reconstruction of avian ancestral karyotypes reveals differences in the evolutionary history of macro- and microchromosomes. Genome Biology, 19 (1). ISSN 1474-760X. (doi:10.1186/s13059-018-1544-8)

Abstract

Background

Here, we make use of the DESCHRAMBLER algorithm to perform the first large-scale study of ancestral chromosome structure and evolution in birds. This algorithm allows us to reconstruct the overall genome structure of 14 key nodes of avian evolution from the Avian ancestor to the ancestor of the Estrildidae, Thraupidae and Fringillidae families.

Conclusions

Analysis of these reconstructions provides important insights into the variability of rearrangement rates during avian evolution and allows the detection of patterns related to the chromosome distribution of evolutionary breakpoint regions. Moreover, the inclusion of microchromosomes in our reconstructions allows us to provide novel insights into the evolution of these avian chromosomes, specifically.

Item Type: Article
DOI/Identification number: 10.1186/s13059-018-1544-8
Uncontrolled keywords: Ancestral karyotypes, Avian, Chromosome evolution, Evolutionary breakpoint regions, Homologous synteny blocks
Subjects: Q Science > QR Microbiology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Darren Griffin
Date Deposited: 17 Oct 2018 15:33 UTC
Last Modified: 23 Jan 2020 04:15 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/69616 (The current URI for this page, for reference purposes)
Farré, Marta: https://orcid.org/0000-0001-9170-5767
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
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