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Controlling the Interfaces of Supramolecular Hydrogels for Tissue Culture Application

Sitsanidis, Efstratios D. Controlling the Interfaces of Supramolecular Hydrogels for Tissue Culture Application. Doctor of Philosophy (PhD) thesis, University of Kent,. (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:69466)

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Abstract

The research work undertaken focused on the preparation and characterization of novel low molecular weight (LMW) hydrogels as functional biomaterials for tissue culture applications. To achieve this objective, new LMW compounds (as potential hydrogelators) were synthesized bearing a galactosamine or glucosamine moiety. The incorporation of carbohydrates was anticipated to confer molecular recognition of certain biomolecules upon the formed supramolecular gels and therefore act as potential anchor sites for cell-binding. The synthesis was based on short synthetic routes and low-cost starting materials were used as supplied. The target compounds were not confined only to those containing carbohydrates. A cinnamoyl-protected diphenylalanine hydrogelator was prepared and the properties of its corresponding hydrogel were investigated.

This project therefore required an interdisciplinary approach which involved the synthesis of a number of LMW compounds where some were found to be hydrogelators. This led to the preparation of their corresponding hydrogels and the study of their microscopic/macroscopic properties for the development of novel biocompatible materials suitable for tissue culture applications.

Item Type: Thesis (Doctor of Philosophy (PhD))
Uncontrolled keywords: Supramolecular, hydrogels, tissue culture
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
SWORD Depositor: System Moodle
Depositing User: System Moodle
Date Deposited: 09 Oct 2018 13:24 UTC
Last Modified: 16 Feb 2021 13:58 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/69466 (The current URI for this page, for reference purposes)
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