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Biotechnological advances in bacterial microcompartment technology

Lee, Matthew J., Palmer, David James, Warren, Martin J. (2019) Biotechnological advances in bacterial microcompartment technology. Trends in Biotechnology, 37 (3). pp. 325-336. ISSN 0167-7799. (doi:10.1016/j.tibtech.2018.08.006) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

Bacterial microcompartments (BMCs) represent proteinaceous macromolecular nano-bioreactors that are found in a broad range of bacteria, and which are associated with either anabolic or catabolic processes. They consist of a semipermeable outer shell that packages a central metabolic enzyme or pathway, providing both enhanced flux and protection against toxic intermediates. Recombinant production of BMCs has led to their repurposing with the incorporation of altogether new pathways. Deconstruction of BMCs into their component parts has shown that some individual shell proteins self-associate into filaments that can be further modified into a cytoplasmic scaffold to which enzymes/proteins can be targeted. BMCs therefore represent a modular system that is highly suited for the engineering of biological systems for useful purposes.

Item Type: Article
DOI/Identification number: 10.1016/j.tibtech.2018.08.006
Uncontrolled keywords: Synthetic biology, metabolic engineering, protein engineering, bacterial microcompartments, shell, metabolism
Subjects: Q Science
Q Science > QR Microbiology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Martin Warren
Date Deposited: 26 Sep 2018 09:24 UTC
Last Modified: 29 May 2019 21:11 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/69249 (The current URI for this page, for reference purposes)
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