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Biotechnological advances in bacterial microcompartment technology

Lee, Matthew J., Palmer, David James, Warren, Martin J. (2019) Biotechnological advances in bacterial microcompartment technology. Trends in Biotechnology, 37 (3). pp. 325-336. ISSN 0167-7799. (doi:10.1016/j.tibtech.2018.08.006) (KAR id:69249)


Bacterial microcompartments (BMCs) represent proteinaceous macromolecular

nano-bioreactors that are found in a broad range of bacteria, and which are

associated with either anabolic or catabolic processes. They consist of a semipermeable

outer shell that packages a central metabolic enzyme or pathway,

providing both enhanced flux and protection against toxic intermediates.

Recombinant production of BMCs has led to their repurposing with the incorporation

of altogether new pathways. Deconstruction of BMCs into their component parts has

shown that some individual shell proteins self-associate into filaments that can be

further modified into a cytoplasmic scaffold to which enzymes/proteins can be

targeted. BMCs therefore represent a modular system that is highly suited for the

engineering of biological systems for useful purposes.

Item Type: Article
DOI/Identification number: 10.1016/j.tibtech.2018.08.006
Uncontrolled keywords: Synthetic biology, metabolic engineering, protein engineering, bacterial microcompartments, shell, metabolism
Subjects: Q Science
Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Martin Warren
Date Deposited: 26 Sep 2018 09:24 UTC
Last Modified: 04 Mar 2024 17:09 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Palmer, David James.

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Warren, Martin J..

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