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Talin as a mechanosensitive signaling hub

Goult, Benjamin T, Yan, Jie, Schwartz, Martin A. (2018) Talin as a mechanosensitive signaling hub. Journal of Cell Biology, 217 (11). pp. 3776-3784. ISSN 0021-9525. (doi:10.1083/jcb.201808061) (KAR id:69244)


Cell adhesion to the extracellular matrix (ECM), mediated by transmembrane receptors of the integrin family, is exquisitely sensitive to biochemical, structural, and mechanical features of the ECM. Talin is a cytoplasmic protein consisting of a globular head domain and a series of ?-helical bundles that form its long rod domain. Talin binds to the cytoplasmic domain of integrin ?-subunits, activates integrins, couples them to the actin cytoskeleton, and regulates integrin signaling. Recent evidence suggests switch-like behavior of the helix bundles that make up the talin rod domains, where individual domains open at different tension levels, exerting positive or negative effects on different protein interactions. These results lead us to propose that talin functions as a mechanosensitive signaling hub that integrates multiple extracellular and intracellular inputs to define a major axis of adhesion signaling.

Item Type: Article
DOI/Identification number: 10.1083/jcb.201808061
Uncontrolled keywords: Cell signaling, Development, Systems and Computational Biology
Subjects: Q Science > QH Natural history > QH301 Biology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Ben Goult
Date Deposited: 25 Sep 2018 20:09 UTC
Last Modified: 09 Dec 2022 03:05 UTC
Resource URI: (The current URI for this page, for reference purposes)

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