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Synthesis and in vitro Bioactivity of Polyunsaturated Fatty Acid Conjugates of Combretastatin A-4

Ojike, Fredrick O., Lavignac, Nathalie, Casely-Hayford, Maxwell A. (2018) Synthesis and in vitro Bioactivity of Polyunsaturated Fatty Acid Conjugates of Combretastatin A-4. Journal of Natural Products, 81 . pp. 2101-2105. ISSN 0163-3864. E-ISSN 1520-6025. (doi:10.1021/acs.jnatprod.7b01062)

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http://dx.doi.org/10.1021/acs.jnatprod.7b01062

Abstract

Combretastatin A-4 (CA-4) (1) is a plant-derived anticancer agent binding to the tubulin

used to improve cell targeting. In the present study, four CA-4-PUFA conjugates were synthesized by

characterized using spectroscopic methods. Their cytotoxicity was evaluated against human breast cancer

influenced tubulin polymerization with the arachidonic acid conjugate (2c) displaying cytotoxicity similar

in potency to the natural product CA-4 (1).

Item Type: Article
DOI/Identification number: 10.1021/acs.jnatprod.7b01062
Subjects: R Medicine
R Medicine > RM Therapeutics. Pharmacology
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Maxwell Casely-Hayford
Date Deposited: 19 Sep 2018 15:27 UTC
Last Modified: 19 Sep 2019 23:00 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/69154 (The current URI for this page, for reference purposes)
Lavignac, Nathalie: https://orcid.org/0000-0002-9259-7603
Casely-Hayford, Maxwell A.: https://orcid.org/0000-0003-4054-4371
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