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Catalytic amine oxidation under ambient aerobic conditions: mimicry of monoamine oxidase B

Murray, Alexander T, Dowley, Myles J H, Pradaux-Caggiano, Fabienne, Baldansuren, Amgalanbaatar, Fielding, Alistair J, Tuna, Floriana, Hendon, Christopher H, Walsh, Aron, Lloyd-Jones, Guy C, John, Matthew P, and others. (2015) Catalytic amine oxidation under ambient aerobic conditions: mimicry of monoamine oxidase B. Angewandte Chemie International Edition, 54 (31). pp. 8997-9000. ISSN 1433-7851. (doi:10.1002/anie.201503654)

Abstract

The flavoenzyme monoamine oxidase (MAO) regulates mammalian behavioral patterns by modulating neurotransmitters such as adrenaline and serotonin. The mechanistic basis which underpins this enzyme is far from agreed upon. Reported herein is that the combination of a synthetic flavin and alloxan generates a catalyst system which facilitates biomimetic amine oxidation. Mechanistic and electron paramagnetic (EPR) spectroscopic data supports the conclusion that the reaction proceeds through a radical manifold. This data provides the first example of a biorelevant synthetic model for monoamine oxidase?B activity.

Item Type: Article
DOI/Identification number: 10.1002/anie.201503654
Additional information: Pre 2016. Previous institution. Couldn't find original pre-formatting so submitted dummy (but article itself is open access!)
Subjects: Q Science > QD Chemistry
Divisions: Faculties > Sciences > School of Physical Sciences
Depositing User: Alex Murray
Date Deposited: 16 Jul 2018 22:49 UTC
Last Modified: 29 May 2019 20:43 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/67644 (The current URI for this page, for reference purposes)
Murray, Alexander T: https://orcid.org/0000-0002-7914-8205
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