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Dependency Relationships within the Fission Yeast Polarity Network

Johnson, Matthew, Mulvihill, Daniel P. (2018) Dependency Relationships within the Fission Yeast Polarity Network. FEBS Letters, 592 (15). pp. 2543-2549. ISSN 0014-5793. (doi:10.1002/1873-3468.13180) (KAR id:67429)

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The ability to regulate polarised cell growth is crucial to maintain the viability

of cells. Growth is modulated to facilitate essential cell functions and respond

to the external environment. Failure to do so can lead to numerous

developmental and disease states including cancer. We have undertaken a

detailed analysis of the regulatory interplay between molecules involved in the

regulation and maintenance of polarised cell growth within fission yeast.

Internally controlled live cell imaging was used to examine interactions

between 10 key polarity proteins. Analysis reveals: interplay between the

microtubule and actin cytoskeletons; multiple novel dependency pathways

and feedback networks between groups of proteins. This study provides

important insights into the conserved regulation of polarised cell growth within


Item Type: Article
DOI/Identification number: 10.1002/1873-3468.13180
Uncontrolled keywords: Schizosaccharomyces pombe, fission yeast, polarised growth, actin, microtubules
Subjects: Q Science
Q Science > QR Microbiology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Daniel Mulvihill
Date Deposited: 27 Jun 2018 15:15 UTC
Last Modified: 04 Jul 2023 12:30 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

Johnson, Matthew.

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Mulvihill, Daniel P..

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