Dependency Relationships within the Fission Yeast Polarity Network

Johnson, Matthew and Mulvihill, Daniel P. (2018) Dependency Relationships within the Fission Yeast Polarity Network. FEBS Letters, . ISSN 0014-5793. (doi:https://doi.org/10.1002/1873-3468.13180) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

The ability to regulate polarised cell growth is crucial to maintain the viability of cells. Growth is modulated to facilitate essential cell functions and respond to the external environment. Failure to do so can lead to numerous developmental and disease states including cancer. We have undertaken a detailed analysis of the regulatory interplay between molecules involved in the regulation and maintenance of polarised cell growth within fission yeast. Internally controlled live cell imaging was used to examine interactions between 10 key polarity proteins. Analysis reveals: interplay between the microtubule and actin cytoskeletons; multiple novel dependency pathways and feedback networks between groups of proteins. This study provides important insights into the conserved regulation of polarised cell growth within eukaryotes.

Item Type: Article
Uncontrolled keywords: Schizosaccharomyces pombe, fission yeast, polarised growth, actin, microtubules
Subjects: Q Science
Q Science > QR Microbiology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Dan Mulvihill
Date Deposited: 27 Jun 2018 15:15 UTC
Last Modified: 24 Sep 2018 09:07 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/67429 (The current URI for this page, for reference purposes)
Mulvihill, Daniel P.: https://orcid.org/0000-0003-2502-5274
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