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Frequent HPV-independent p16/INK4A overexpression in head and neck cancer

Lechner, Matt, Chakravarthy, Ankur R., Walter, Vonn, Masterson, Liam, Feber, Andrew, Jay, Amrita, Weinberger, Paul M., McIndoe, Richard A., Forde, Cillian T., Chester, Kerry, and others. (2018) Frequent HPV-independent p16/INK4A overexpression in head and neck cancer. Oral Oncology, 83 . pp. 32-37. ISSN 1368-8375. (doi:10.1016/j.oraloncology.2018.06.006) (KAR id:67260)

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https://doi.org/10.1016/j.oraloncology.2018.06.006

Abstract

Objectives

We integrated reverse phase protein array (RPPA) data for p16 with HPV status based on detection of viral transcripts by RNA-seq in a set of 210 HNSCCs profiled by The Cancer Genome Atlas project. Samples were queried for alterations in CDKN2A, and other pathway genes to investigate possible drivers of p16 expression.

Results

RPPA data suggest high p16 protein expression in many HPV (?) non-oropharyngeal HNSCCs, limiting its potential utility as an HPV biomarker outside of the oropharynx. HPV-independent overexpression of wild-type p16 in non-oropharyngeal HNSCC may be linked to global deregulation of chromatin state by inactivating mutations in NSD1.

Item Type: Article
DOI/Identification number: 10.1016/j.oraloncology.2018.06.006
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Tim Fenton
Date Deposited: 11 Jun 2018 11:45 UTC
Last Modified: 09 Jun 2019 23:00 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/67260 (The current URI for this page, for reference purposes)
Fenton, TR: https://orcid.org/0000-0002-4737-8233
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