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Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster

Augustin, Hrvoje, McGourty, Kieran, Allen, Marcus J., Adcott, Jennifer, Wong, Chi Tung, Boucrot, Emmanuel, Partridge, Linda (2018) Impact of insulin signaling and proteasomal activity on physiological output of a neuronal circuit in aging Drosophila melanogaster. Neurobiology of Aging, 66 . pp. 149-157. ISSN 0197- 4580. (doi:10.1016/j.neurobiolaging.2018.02.027)

Abstract

The insulin family of growth factors plays an important role in development and function of the nervous system. Reduced insulin and insulin-growth-factor signaling (IIS), however, can improve symptoms of neurodegenerative diseases in laboratory model organisms and protect against age-associated decline in neuronal function. Recently, we showed that chronic, moderately lowered IIS rescues age-related decline in neurotransmission through the Drosophila giant fiber escape response circuit. Here, we expand our initial findings by demonstrating that reduced functional output in the giant fiber system of aging flies can be prevented by increasing proteasomal activity within the circuit. Manipulations of IIS in neurons can also affect longevity, underscoring the relevance of the nervous system for aging.

Item Type: Article
DOI/Identification number: 10.1016/j.neurobiolaging.2018.02.027
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 24 May 2018 09:10 UTC
Last Modified: 29 May 2019 20:34 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/67118 (The current URI for this page, for reference purposes)
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