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Degradable Polymers and Nanoparticles Built from Salicylic Acid

Akkad, M. Saeed, Serpell, Christopher J. (2018) Degradable Polymers and Nanoparticles Built from Salicylic Acid. Macromolecular Rapid Communications, 39 (14). Article Number 1800182. ISSN 1022-1336. (doi:10.1002/marc.201800182) (KAR id:66979)

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https://doi.org/10.1002/marc.201800182

Abstract

As more evidence emerges supporting the possibility that non-steroidal anti-inflammatory drugs, especially aspirin (acetyl salicylic acid), might have a role in the prevention and management in certain types of cancer, there have been several attempts to fabricate salicylic acid-based polymers that can be employed in the targeted therapy of tumours. The primary disadvantage so far has been in use of non-therapeutic polymeric backbones that constitute the majority of the therapeutic particle’s size. The focus of this research is the creation of a biodegradable polymer consisting only of salicylic acid, and its use as the main building block in targeted nanotherapeutics that would consequently provide both high local dose and sustained release of the active moiety. In this work, we demonstrate the synthesis and degradation of polysalicylates, and modulation of their size and hydrolytic stability through formation of nanostructures.

Item Type: Article
DOI/Identification number: 10.1002/marc.201800182
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > School of Physical Sciences
Depositing User: Christopher Serpell
Date Deposited: 10 May 2018 13:54 UTC
Last Modified: 16 Feb 2021 13:54 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66979 (The current URI for this page, for reference purposes)
Serpell, Christopher J.: https://orcid.org/0000-0002-2848-9077
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