Degradable Polymers and Nanoparticles Built from Salicylic Acid

Akkad, M. Saeed and Serpell, Christopher J. (2018) Degradable Polymers and Nanoparticles Built from Salicylic Acid. Macromolecular Rapid Communications, . ISSN 1022-1336. (doi:https://doi.org/10.1002/marc.201800182) (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

PDF - Author's Accepted Manuscript
Restricted to Repository staff only until 22 May 2019.
Contact us about this Publication Download (564kB)
[img]
Official URL
https://doi.org/10.1002/marc.201800182

Abstract

As more evidence emerges supporting the possibility that non-steroidal anti-inflammatory drugs, especially aspirin (acetyl salicylic acid), might have a role in the prevention and management in certain types of cancer, there have been several attempts to fabricate salicylic acid-based polymers that can be employed in the targeted therapy of tumours. The primary disadvantage so far has been in use of non-therapeutic polymeric backbones that constitute the majority of the therapeutic particle’s size. The focus of this research is the creation of a biodegradable polymer consisting only of salicylic acid, and its use as the main building block in targeted nanotherapeutics that would consequently provide both high local dose and sustained release of the active moiety. In this work, we demonstrate the synthesis and degradation of polysalicylates, and modulation of their size and hydrolytic stability through formation of nanostructures.

Item Type: Article
Divisions: Faculties > Sciences > School of Physical Sciences
Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Christopher Serpell
Date Deposited: 10 May 2018 13:54 UTC
Last Modified: 23 Jul 2018 09:14 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66979 (The current URI for this page, for reference purposes)
Serpell, Christopher J.: https://orcid.org/0000-0002-2848-9077
  • Depositors only (login required):

Downloads

Downloads per month over past year