Akkad, M. Saeed, Serpell, Christopher J. (2018) Degradable Polymers and Nanoparticles Built from Salicylic Acid. Macromolecular Rapid Communications, 39 (14). Article Number 1800182. ISSN 1022-1336. (doi:10.1002/marc.201800182) (KAR id:66979)
PDF
Author's Accepted Manuscript
Language: English |
|
Download this file (PDF/806kB) |
Preview |
Request a format suitable for use with assistive technology e.g. a screenreader | |
Official URL: https://doi.org/10.1002/marc.201800182 |
Abstract
As more evidence emerges supporting the possibility that non-steroidal anti-inflammatory drugs, especially aspirin (acetyl salicylic acid), might have a role in the prevention and management in certain types of cancer, there have been several attempts to fabricate salicylic acid-based polymers that can be employed in the targeted therapy of tumours. The primary disadvantage so far has been in use of non-therapeutic polymeric backbones that constitute the majority of the therapeutic particle’s size. The focus of this research is the creation of a biodegradable polymer consisting only of salicylic acid, and its use as the main building block in targeted nanotherapeutics that would consequently provide both high local dose and sustained release of the active moiety. In this work, we demonstrate the synthesis and degradation of polysalicylates, and modulation of their size and hydrolytic stability through formation of nanostructures.
Item Type: | Article |
---|---|
DOI/Identification number: | 10.1002/marc.201800182 |
Subjects: | Q Science |
Divisions: | Divisions > Division of Natural Sciences > Physics and Astronomy |
Depositing User: | Christopher Serpell |
Date Deposited: | 10 May 2018 13:54 UTC |
Last Modified: | 04 Mar 2024 15:31 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/66979 (The current URI for this page, for reference purposes) |
- Link to SensusAccess
- Export to:
- RefWorks
- EPrints3 XML
- BibTeX
- CSV
- Depositors only (login required):