The tale of two talins – two isoforms to fine-tune integrin signalling

Talins are cytoplasmic adapter proteins essential for integrin-mediated cell adhesion to the

actin, recruit numerous signalling molecules that mediate integrin signalling, and coordinate

containing) proteins. Vertebrates have two talin genes, TLN1 and TLN2. Although talin1 and

and the differences between the two isoforms are not fully understood. In this Review, we focus

and function, which hint at subtle differences in fine-tuning adhesion signalling.