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Autophagy diminishes the early interferon- ? response to influenza A virus resulting in differential expression of interferon- stimulated genes

Perot, B, Boussier, J, Yatim, N, Rossman, Jeremy S., Ingersoll, M, Albert, M (2018) Autophagy diminishes the early interferon- ? response to influenza A virus resulting in differential expression of interferon- stimulated genes. Cell death & disease, . ISSN 2041-4889. (doi:10.1038/s41419-018-0546-5) (KAR id:66887)

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Abstract

Influenza A virus (IAV) infection perturbs metabolic pathways such as autophagy, a stress-induced catabolic pathway

expression or host cell responses remains disputed. Discrepant results may be a reflection of in vivo studies using cellspecific

programmes from more proximal effects on inflammatory response. In vitro experiments can be confounded by gene

autophagy. With the goal to investigate cellular processes within cells that are competent or incompetent for

stabilization in an otherwise Atg5-deficient background. We confirmed that IAV induced autophagosome formation

infection or replication in ATG5-stablized cells. Notably, the induction of interferon-stimulated genes (ISGs) by IAV was

interferon-? (IFN-?) expression was increased as compared to levels in autophagy-competent lines, a

IAV infection reduces ISG expression in infected cells by limiting IFN-? expression, which may benefit viral replication

and spread.

Item Type: Article
DOI/Identification number: 10.1038/s41419-018-0546-5
Subjects: Q Science > QR Microbiology > QR180 Immunology
Q Science > QR Microbiology > QR355 Virology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Jeremy Rossman
Date Deposited: 02 May 2018 08:54 UTC
Last Modified: 29 May 2019 20:30 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66887 (The current URI for this page, for reference purposes)
Rossman, Jeremy S.: https://orcid.org/0000-0001-6124-4103
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