Skip to main content

Ebolaviruses: New roles for old proteins

Cantoni, Diego, Rossman, Jeremy S. (2018) Ebolaviruses: New roles for old proteins. PLOS Neglected Tropical Diseases, 12 (5). Article Number 6349. ISSN 1935-2735. (doi:10.1371/journal.pntd.0006349) (KAR id:66886)


In 2014, the world witnessed the largest Ebolavirus outbreak in recorded history. The subsequent humanitarian effort spurred extensive research, significantly enhancing our understanding of ebolavirus replication and pathogenicity. The main functions of each ebolavirus protein have been studied extensively since the discovery of the virus in 1976; however, the recent expansion of ebolavirus research has led to the discovery of new protein functions. These newly discovered roles are revealing new mechanisms of virus replication and pathogenicity, whilst enhancing our understanding of the broad functions of each ebolavirus viral protein (VP). Many of these new functions appear to be unrelated to the protein’s primary function during virus replication. Such new functions range from bystander T-lymphocyte death caused by VP40-secreted exosomes to new roles for VP24 in viral particle formation. This review highlights the newly discovered roles of ebolavirus proteins in order to provide a more encompassing view of ebolavirus replication and pathogenicity.

Item Type: Article
DOI/Identification number: 10.1371/journal.pntd.0006349
Subjects: Q Science > QR Microbiology > QR355 Virology
Divisions: Divisions > Division of Natural Sciences > Biosciences
Depositing User: Jeremy Rossman
Date Deposited: 02 May 2018 08:34 UTC
Last Modified: 09 Dec 2022 03:57 UTC
Resource URI: (The current URI for this page, for reference purposes)

University of Kent Author Information

  • Depositors only (login required):

Total unique views for this document in KAR since July 2020. For more details click on the image.