Sanfelice, Domenico, Koss, Hans, Bunney, Tom D., Thompson, Gary S., Farrell, Brendan, Katan, Matilda, Breeze, Alexander L. (2018) NMR backbone assignments of the tyrosine kinase domain of human fibroblast growth factor receptor 3 in apo state and in complex with inhibitor PD173074. Biomolecular NMR Assignments, 12 (2). pp. 231-235. ISSN 1874-2718. E-ISSN 1874-270X. (doi:10.1007/s12104-018-9814-7) (KAR id:66867)
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| Official URL https://doi.org/10.1007/s12104-018-9814-7 |
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Abstract
Fibroblast growth factors receptors (FGFR) are transmembrane protein tyrosine kinases involved in many cellular process,
disorders and cancers; therefore FGFRs have become attractive targets for drug discovery, with a number of agents
ligand-free form and in complex with the canonical FGFR kinase inhibitor PD173074. Analysis of chemical shift changes
drug discovery activities aimed at development of conformationally-selective FGFR inhibitors.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1007/s12104-018-9814-7 |
| Uncontrolled keywords: | Fibroblast growth factor receptor 3 Tyrosine kinase inhibitor NMR resonance assignment Cancer Angiogenesis |
| Divisions: | Divisions > Division of Natural Sciences > School of Biosciences |
| Depositing User: | Gary Thompson |
| Date Deposited: | 30 Apr 2018 09:21 UTC |
| Last Modified: | 29 May 2019 20:30 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/66867 (The current URI for this page, for reference purposes) |
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