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3D printed microneedles for insulin skin delivery

Pere, Cristiane Patricia Pissinato, Economidou, Sophia N., Lall, Gurprit S., Ziraud, Clémentine, Boateng, Joshua S., Alexander, Bruce D., Lamprou, Dimitrios A., Douroumis, Dennis (2018) 3D printed microneedles for insulin skin delivery. International Journal of Pharmaceutics, 544 (2). pp. 425-432. ISSN 0378-5173. (doi:10.1016/j.ijpharm.2018.03.031)

Abstract

In this study, polymeric microneedle patches were fabricated by stereolithography, a 3D printing technique, for the transdermal delivery of insulin. A biocompatible resin was photopolymerized to build pyramid and cone microneedle designs followed by inkjet print coating of insulin formulations., trehalose and xylitol were used as drug carriers with the aim to preserve insulin integrity and stability but also facilitate rapid release rates. Circular dichroism and Raman analysis demonstrated that all carriers maintained the native form of insulin with xylitol presenting the best performance. Franz cell release studies were used for in vitro determination of insulin release rates in porcine skin. Insulin was released rapidly within 30 min irrespectively of the microneedle design. 3D printing was proved an effective technology for the fabrication of biocompatible and scalable microneedle patches.

Item Type: Article
DOI/Identification number: 10.1016/j.ijpharm.2018.03.031
Uncontrolled keywords: 3D printing, microneedles, inkjet coating, insulin
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Gurprit Lall
Date Deposited: 17 Apr 2018 08:41 UTC
Last Modified: 29 May 2019 20:28 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66739 (The current URI for this page, for reference purposes)
Lall, Gurprit S.: https://orcid.org/0000-0003-3725-4795
Lamprou, Dimitrios A.: https://orcid.org/0000-0002-8740-1661
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