Pere, Cristiane Patricia Pissinato, Economidou, Sophia N., Lall, Gurprit S., Ziraud, Clémentine, Boateng, Joshua S., Alexander, Bruce D., Lamprou, Dimitrios A., Douroumis, Dennis (2018) 3D printed microneedles for insulin skin delivery. International Journal of Pharmaceutics, 544 (2). pp. 425-432. ISSN 0378-5173. (doi:10.1016/j.ijpharm.2018.03.031) (KAR id:66739)
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Official URL: https://doi.org/10.1016/j.ijpharm.2018.03.031 |
Abstract
In this study, polymeric microneedle patches were fabricated by stereolithography, a 3D printing technique, for the transdermal delivery of insulin. A biocompatible resin was photopolymerized to build pyramid and cone microneedle designs followed by inkjet print coating of insulin formulations., trehalose and xylitol were used as drug carriers with the aim to preserve insulin integrity and stability but also facilitate rapid release rates. Circular dichroism and Raman analysis demonstrated that all carriers maintained the native form of insulin with xylitol presenting the best performance. Franz cell release studies were used for in vitro determination of insulin release rates in porcine skin. Insulin was released rapidly within 30 min irrespectively of the microneedle design. 3D printing was proved an effective technology for the fabrication of biocompatible and scalable microneedle patches.
Item Type: | Article |
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DOI/Identification number: | 10.1016/j.ijpharm.2018.03.031 |
Uncontrolled keywords: | 3D printing, microneedles, inkjet coating, insulin |
Divisions: | Divisions > Division of Natural Sciences > Medway School of Pharmacy |
Depositing User: | Gurprit Lall |
Date Deposited: | 17 Apr 2018 08:41 UTC |
Last Modified: | 08 Dec 2022 23:42 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/66739 (The current URI for this page, for reference purposes) |
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