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Establishing Cryptosporidium parvum as a model organism

Miller, Christopher (2017) Establishing Cryptosporidium parvum as a model organism. Doctor of Philosophy (PhD) thesis, University of Kent,. (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided) (KAR id:66710)

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Language: English

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Abstract

Cryptosporidium parvum is among the most common parasites in the known world and

apicomplexan, C. parvum has many similarities to other globally important parasites such

complex life cycle and the ability to invade host cells. However, unlike most other

apicoplast, and drastically reduced the size of their genome. For decades this caused

recent phylogenetic studies that revealed a strong relationship between the cryptosporidia

reclassification to include the cryptosporidia. Though research into apicomplexan

portion. This is largely due to the lack of molecular tools and culturing techniques that

medical irrelevance prior to the inclusion of Cryptosporidium.

evolutionary adaptations of apicomplexans from invertebrate to vertebrate hosts. It was

be required to begin developing C. parvum as such. To achieve this, first I successfully

a live parasite culture for 60 days. Additionally, I developed novel methods of detecting

metabolomes which also revealed a potentially more involved role for Taurine in the

this new system I produced the first experimental evidence for a functional ISC system

containing organisms that still maintain an active mitochondrial Fe/S cluster biosynthetic

In conclusion, this thesis represents a large step forward for both the C. parvum and

in understanding these apicomplexans and their organelles.

Item Type: Thesis (Doctor of Philosophy (PhD))
Thesis advisor: Tsaousis, Anastasios
Uncontrolled keywords: Model organism, cryptosporidium, parasitology, mitochondria, mitosome, microscopy, iron sulphur clusters, thesis, 4 years, mice
Divisions: Faculties > Sciences > School of Biosciences
SWORD Depositor: System Moodle
Depositing User: System Moodle
Date Deposited: 12 Apr 2018 15:10 UTC
Last Modified: 22 Jan 2020 04:11 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66710 (The current URI for this page, for reference purposes)
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