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A new approach for interpreting Random Forest models and its application to the biology of ageing

Fabris, Fabio, Doherty, Aoife, Palmer, Daniel, de Magalhães, João Pedro, Freitas, Alex A. (2018) A new approach for interpreting Random Forest models and its application to the biology of ageing. Bioinformatics, 34 (14). pp. 2449-2456. ISSN 1367-4803. (doi:10.1093/bioinformatics/bty087) (KAR id:66666)

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This work uses the Random Forest (RF) classification algorithm to predict if a gene is over-expressed, under-expressed or has no change in expression with age in the brain. RFs have high predictive power, and RF models can be interpreted using a feature (variable) importance measure. However, current feature importance measures evaluate a feature as a whole (all feature values). We show that, for a popular type of biological data (Gene Ontology-based), usually only one value of a feature is particularly important for classification and the interpretation of the RF model. Hence, we propose a new algorithm for identifying the most important and most informative feature values in an RF model.

Item Type: Article
DOI/Identification number: 10.1093/bioinformatics/bty087
Uncontrolled keywords: machine learning, classification, bioinformatics, data mining
Subjects: Q Science > Q Science (General) > Q335 Artificial intelligence
Divisions: Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Depositing User: Alex Freitas
Date Deposited: 09 Apr 2018 10:44 UTC
Last Modified: 16 Feb 2021 13:54 UTC
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