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The impact of sample size on the reproducibility of voxel-based lesion-deficit mappings

Lorca-Puls, Diego L., Gajardo-Vidal, Andrea, White, Jitrachote, Seghier, Mohamed L., Leff, Alexander P., Green, David W., Crinion, Jenny T., Ludersdorfer, Philipp, Hope, Thomas M.H., Bowman, Howard, and others. (2018) The impact of sample size on the reproducibility of voxel-based lesion-deficit mappings. Neuropsychologia, . ISSN 0028-3932. (doi:10.1016/j.neuropsychologia.2018.03.014) (KAR id:66579)

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https://doi.org/10.1016/j.neuropsychologia.2018.03...

Abstract

This study investigated how sample size affects the reproducibility of findings from univariate voxel-based lesion-deficit analyses (e.g., voxel-based lesion-symptom mapping and voxel-based morphometry). Our effect of interest was the strength of the mapping between brain damage and speech articulation difficulties, as measured in terms of the proportion of variance explained. First, we identified a region of interest by searching on a voxel-by-voxel basis for brain areas where greater lesion load was associated with poorer speech articulation using a large sample of 360 right-handed English-speaking stroke survivors. We then randomly drew thousands of bootstrap samples from this data set that included either 30, 60, 90, 120, 180, or 360 patients. For each resample, we recorded effect size estimates and p values after conducting exactly the same lesion-deficit analysis within the previously identified region of interest and holding all procedures constant. The results show (1) how often small effect sizes in a heterogeneous population fail to be detected; (2) how effect size and its statistical significance varies with sample size; (3) how low-powered studies (due to small sample sizes) can greatly over-estimate as well as under-estimate effect sizes; and (4) how large sample sizes (N ? 90) can yield highly significant p values even when effect sizes are so small that they become trivial in practical terms. The implications of these findings for interpreting the results from univariate voxel-based lesion-deficit analyses are discussed.

Item Type: Article
DOI/Identification number: 10.1016/j.neuropsychologia.2018.03.014
Uncontrolled keywords: Voxel-based, Lesion-symptom, Lesion, Deficit, Reproducibility, Stroke, Speech production
Divisions: Divisions > Division of Computing, Engineering and Mathematical Sciences > School of Computing
Depositing User: Howard Bowman
Date Deposited: 29 Mar 2018 10:15 UTC
Last Modified: 16 Feb 2021 13:53 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66579 (The current URI for this page, for reference purposes)
Bowman, Howard: https://orcid.org/0000-0003-4736-1869
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