Skip to main content

Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2

Khan, Mohammad Farhan, Spurgeon, Sarah K., von der Haar, Tobias (2018) Origins of robustness in translational control via eukaryotic translation initiation factor (eIF) 2. Journal of Theoretical Biology, 445 . pp. 92-102. ISSN 0022-5193. (doi:10.1016/j.jtbi.2018.02.020) (KAR id:66562)

PDF (Accepted manuscript including changes in response to reviewers' comments) Author's Accepted Manuscript
Language: English


Creative Commons Licence
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.
Download (803kB) Preview
[img]
Preview
Official URL
https://doi.org/10.1016/j.jtbi.2018.02.020

Abstract

Phosphorylation of eukaryotic translation initiation factor 2 (eIF2) is one of the best studied and most widely used means for regulating protein synthesis activity in eukaryotic cells. This pathway regulates protein synthesis in response to stresses, viral infections, and nutrient depletion, among others. We present analyses of an ordinary differential equation-based model of this pathway, which aim to identify its principal robustness-conferring features. Our analyses indicate that robustness is a distributed property, rather than arising from the properties of any one individual pathway species. However, robustness-conferring properties are unevenly distributed between the different species, and we identify a guanine nucleotide dissociation inhibitor (GDI) complex as a species that likely contributes strongly to the robustness of the pathway. Our analyses make further predictions on the dynamic response to different types of kinases that impinge on eIF2.

Item Type: Article
DOI/Identification number: 10.1016/j.jtbi.2018.02.020
Additional information: Contact Email address: T.von-der-Haar@kent.ac.uk
Uncontrolled keywords: Protein synthesis, Translation, Translational control, eIF2, eIF2B, Gcn2, Control engineering, Robustness
Subjects: Q Science > QP Physiology (Living systems) > QP506 Molecular biology
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Tobias von der Haar
Date Deposited: 28 Mar 2018 10:09 UTC
Last Modified: 29 May 2019 20:24 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66562 (The current URI for this page, for reference purposes)
von der Haar, Tobias: https://orcid.org/0000-0002-6031-9254
  • Depositors only (login required):

Downloads

Downloads per month over past year