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Trial of aminoglutethimide vs hydrocortisone as second-line hormone treatment of advanced breast cancer

Mercer, P.M., Ebbs, S.R., Fraser, S.C.A., Coltart, R.S., Bates, Tom (1993) Trial of aminoglutethimide vs hydrocortisone as second-line hormone treatment of advanced breast cancer. European Journal of Surgical Oncology, 19 (3). pp. 254-258. ISSN 0748-7983. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:66400)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
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Abstract

In a randomised trial of second line hormone therapy 56 postmenopausal women with advanced breast cancer received low dose aminoglutethimide (AGT) 125 mg twice daily without hydrocortisone (27 patients), or hydrocortisone (HC) 20 mg twice daily (29 patients). The two groups were well-matched for previous response to tamoxifen (TAM) therapy (AGT (35%) vs HC (32%)) and for relapse on adjuvant TAM. The mean age of the two groups was 69.2 years (AGT) and 63.2 years (HC). Liver metastases were present in 29% (AGT) and 33% (HC). The response rates were 11% (AGT) and 21% (HC). At 12 months the failure of treatment rate was 80% (AGT) and 70% HC. Survival at 12 months was 50% for both groups. At 12 months 5/12 survivors were still on AGT and 8/12 on HC. These preliminary findings have so far failed to show any statistical difference in tumour response, time to treatment failure or survival between low-dose AGT and HC as second-line hormone treatment post-tamoxifen in advanced breast cancer.

Item Type: Article
Additional information: Unmapped bibliographic data: DB - Scopus [Field not mapped to EPrints] M3 - Article [Field not mapped to EPrints]
Uncontrolled keywords: Aminoglutethimide, Breast neoplasm, Hydrocortisone
Divisions: Divisions > Directorate of Education > School of Education
Depositing User: Bates Tom
Date Deposited: 15 Jan 2019 13:44 UTC
Last Modified: 16 Nov 2021 10:25 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66400 (The current URI for this page, for reference purposes)
Bates, Tom: https://orcid.org/0000-0001-5554-1945
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