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The Relationship between Cholecystectomy, Unoperated Gallstone Disease, and Colorectal Cancer: A Necropsy Study

Mercer, P.M., Reid, F.D.A., Harrison, M., Bates, Tom (1995) The Relationship between Cholecystectomy, Unoperated Gallstone Disease, and Colorectal Cancer: A Necropsy Study. Scandinavian Journal of Gastroenterology, 30 (10). pp. 1017-1020. ISSN 0036-5521. (doi:10.3109/00365529509096347) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:66399)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL
https://doi.org/10.3109/00365529509096347

Abstract

Background: There may be an increased risk of colorectal cancer after cholecystectomy, but the literature is not consistent. It is also possible that any risk might be associated with gallstones rather than cholecystectomy. Methods: In a prospective necropsy study of 8563 cases, all 219 cases of a previous cholecystectomy were pair-matched to subjects with gallstones and to subjects with a normal gallbladder. In a second study all 192 cases of colorectal cancers were pair-matched to cancer-free subjects. Results: The odds ratio (OR) for developing colorectal cancer after cholecystectomy compared with a normal gallbladder was 1.0 (95% confidence interval, 0.30-3.34) and with unoperated gallstones was 0.88 (0.27-2.76). Conclusions: This study fails to support an association between cholecystectomy or gallstones and colorectal cancer. For those cases of colorectal cancer versus controls, the OR for previous cholecystectomy was 0.70 (0.23-2.04) and for gallstone disease was 0.93 (0.58-1.48).

Item Type: Article
DOI/Identification number: 10.3109/00365529509096347
Additional information: Unmapped bibliographic data: DB - Scopus [Field not mapped to EPrints] M3 - Article [Field not mapped to EPrints]
Uncontrolled keywords: Cholecystectomy, Colorectal cancer, Epidemiology, Gallstones, Necropsy study
Divisions: Divisions > Directorate of Education > School of Education
Depositing User: Bates Tom
Date Deposited: 15 Jan 2019 13:37 UTC
Last Modified: 16 Nov 2021 10:25 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66399 (The current URI for this page, for reference purposes)
Bates, Tom: https://orcid.org/0000-0001-5554-1945
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