Reid, F.D.A., Mercer, P.M., Harrison, M., Bates, Tom (1996) Cholecystectomy as a risk factor for colorectal cancer: A meta-analysis. Scandinavian Journal of Gastroenterology, 31 (2). pp. 160-169. ISSN 0036-5521. (doi:10.3109/00365529609031981) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:66397)
The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. | |
Official URL: https://doi.org/10.3109/00365529609031981 |
Abstract
Background: It has been suggested that there is an increased risk of colorectal cancer after cholecystectomy due to increased levels of secondary bile acids. Some studies suggest the risk is higher for women and for the development of right-sided tumours. Methods: A review of the literature yielded 95 relevant studies, of which 35 were suitable for a meta-analysis involving age- and sex-matched controls. Results: The pooled. odds ratio for a positive association between cholecystectomy and colorectal cancer was 1.11 (95% confidence interval (CI), 1.02 to 1.21). For women the odds ratio was 1.14 (95% CI, 1.01 to 1.28), and for right-sided cancer 1.86 (95% CI, 1.31 to 2.65). Conclusions: It is possible that this small observed association may be due to a publication bias for positive results or bias within the included studies. If it is indeed a real effect, the risk to an individual is very small.
Item Type: | Article |
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DOI/Identification number: | 10.3109/00365529609031981 |
Additional information: | Unmapped bibliographic data: DB - Scopus [Field not mapped to EPrints] M3 - Article [Field not mapped to EPrints] |
Uncontrolled keywords: | Cholecystectomy, Colorectal cancer, Epidemiology, Meta-analysis |
Divisions: | Divisions > Directorate of Education > School of Education |
Depositing User: | Bates Tom |
Date Deposited: | 15 Jan 2019 13:32 UTC |
Last Modified: | 16 Nov 2021 10:25 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/66397 (The current URI for this page, for reference purposes) |
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