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Cholecystectomy as a risk factor for colorectal cancer: A meta-analysis

Reid, F.D.A., Mercer, P.M., Harrison, M., Bates, Tom (1996) Cholecystectomy as a risk factor for colorectal cancer: A meta-analysis. Scandinavian Journal of Gastroenterology, 31 (2). pp. 160-169. ISSN 0036-5521. (doi:10.3109/00365529609031981) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:66397)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL
https://doi.org/10.3109/00365529609031981

Abstract

Background: It has been suggested that there is an increased risk of colorectal cancer after cholecystectomy due to increased levels of secondary bile acids. Some studies suggest the risk is higher for women and for the development of right-sided tumours. Methods: A review of the literature yielded 95 relevant studies, of which 35 were suitable for a meta-analysis involving age- and sex-matched controls. Results: The pooled. odds ratio for a positive association between cholecystectomy and colorectal cancer was 1.11 (95% confidence interval (CI), 1.02 to 1.21). For women the odds ratio was 1.14 (95% CI, 1.01 to 1.28), and for right-sided cancer 1.86 (95% CI, 1.31 to 2.65). Conclusions: It is possible that this small observed association may be due to a publication bias for positive results or bias within the included studies. If it is indeed a real effect, the risk to an individual is very small.

Item Type: Article
DOI/Identification number: 10.3109/00365529609031981
Additional information: Unmapped bibliographic data: DB - Scopus [Field not mapped to EPrints] M3 - Article [Field not mapped to EPrints]
Uncontrolled keywords: Cholecystectomy, Colorectal cancer, Epidemiology, Meta-analysis
Divisions: Divisions > Directorate of Education > School of Education
Depositing User: Bates Tom
Date Deposited: 15 Jan 2019 13:32 UTC
Last Modified: 16 Nov 2021 10:25 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66397 (The current URI for this page, for reference purposes)
Bates, Tom: https://orcid.org/0000-0001-5554-1945
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