Skip to main content

Metronidazole v. cefoxitin in severe appendicitis-a trial to compare a single intraoDerative dose of two antibiotics given intravenously

Corder, A.P., Bates, Tom, Prior, J.E., Harrison, M., Donaldson, P.J. (1983) Metronidazole v. cefoxitin in severe appendicitis-a trial to compare a single intraoDerative dose of two antibiotics given intravenously. Postgraduate Medical Journal, 59 (697). pp. 720-723. ISSN 0032-5473. (doi:10.1136/pgmj.59.697.720) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:66385)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided.
Official URL
http://dx.doi.org/10.1136/pgmj.59.697.720

Abstract

In severe appendicitis, the effect of a single intravenous dose of metronidazole (500 mg) was compared with cefoxitin (1 g). The antibiotics were given by random allocation once the diagnosis had been established at operation. In the metronidazole group, 5 out of 48 patients developed a wound infection whilst in hospital compared with 13 out of 48 in the cefoxitin group (P=0-036). However, 57% of wound infections became apparent after the patient went home and the overall infection rates were similar. The mean length of postoperative hospital stay was 5-0 days in the metronidazole group and 6-8 days in the cefoxitin group (P= 0052), but of those who did develop a wound infection, the length of stay was almost double in the cefoxitin group. Anaerobic organisms were cultured from the wound in 7 out of 15 patients who received cefoxitin but in none of 5 patients in the metronidazole group. Whilst metronidazole only delayed the discharge of pus from the wound, it did seem to reduce the severity of infection. Cefoxitin appeared to be less effective, given as a single intravenous injection at a dose of 1 g.

Item Type: Article
DOI/Identification number: 10.1136/pgmj.59.697.720
Additional information: Unmapped bibliographic data: DB - Scopus [Field not mapped to EPrints] M3 - Article [Field not mapped to EPrints]
Uncontrolled keywords: Appendicitis, Cefoxitin, Metronidazole, Wound infection
Divisions: Divisions > Directorate of Education > School of Education
Depositing User: Bates Tom
Date Deposited: 15 Jan 2019 15:44 UTC
Last Modified: 16 Nov 2021 10:25 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66385 (The current URI for this page, for reference purposes)
Bates, Tom: https://orcid.org/0000-0001-5554-1945
  • Depositors only (login required):