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Ras signalling in pathogenic yeasts

Pentland, Daniel R, Piper-Brown, Elliot, Mühlschlegel, Fritz A., Gourlay, Campbell W. (2017) Ras signalling in pathogenic yeasts. Microbial Cell, 5 (2). pp. 63-73. ISSN 2311-2638. (doi:10.15698/mic2018.02.612) (KAR id:66047)

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http://dx.doi.org/10.15698/mic2018.02.612

Abstract

The small GTPase Ras acts as a master regulator of growth, stress response and cell death in eukaryotic cells. The control of Ras activity is fundamental, as highlighted by the oncogenic properties of constitutive forms of Ras proteins. Ras also plays a crucial role in the pathogenicity of fungal pathogens where it has been found to regulate a number of adaptions required for virulence. The importance of Ras in fungal disease raises the possibility that it may provide a useful target for the development of new treatments at a time when resistance to available antifungals is increasing. New findings suggest that important regulatory sequences found within fungal Ras proteins that are not conserved may prove useful in the development of new antifungals. Here we review the roles of Ras protein function and signalling in the major human yeast pathogensandand discuss the potential for targeting Ras as a novel approach to anti-fungal therapy.

Item Type: Article
DOI/Identification number: 10.15698/mic2018.02.612
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Campbell Gourlay
Date Deposited: 16 Feb 2018 14:09 UTC
Last Modified: 29 May 2019 20:16 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66047 (The current URI for this page, for reference purposes)
Gourlay, Campbell W.: https://orcid.org/0000-0002-2373-6788
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