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Tim-3 as a signalling receptor expressed by leukaemia cells and potential target for highly specific drug delivery

Bernardo Goncalves Oliveira Silva, Isabel (2017) Tim-3 as a signalling receptor expressed by leukaemia cells and potential target for highly specific drug delivery. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:66029)

Abstract

Leukaemia is a blood/bone marrow cancer caused by malignant immature hematopoietic

that has the highest number of lethal outcomes is Acute Myeloid Leukaemia (AML) where

We discovered a fundamental biochemical mechanism in AML cells, which includes ligand

other G-protein coupled receptors, leading to upregulated translation and secretion of the

the mammalian target of rapamycin (mTOR). Tim-3 was observed to participate in galectin-9

activities of cytotoxic lymphoid cells including natural killer (NK) cells and soluble Tim-3

cytotoxic lymphoid cells.

This fundamental pathway provides reliable targets for both highly specific diagnosis and

Furthermore, we demonstrated that the Tim-3/galectin-9 autocrine loop has intracellular

pathway controlled by mTOR.

Item Type: Thesis (Doctor of Philosophy (PhD))
Thesis advisor: Sumbayev, Vadim
Thesis advisor: Gibbs, Bernhard
Uncontrolled keywords: AML, Acute Myeloid leukaemia, Tim-3, Gal-9, Lphn
Divisions: Faculties > Sciences > Medway School of Pharmacy
SWORD Depositor: System Moodle
Depositing User: System Moodle
Date Deposited: 15 Feb 2018 10:17 UTC
Last Modified: 06 May 2020 03:17 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/66029 (The current URI for this page, for reference purposes)
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