Bernardo Goncalves Oliveira Silva, Isabel (2017) Tim-3 as a signalling receptor expressed by leukaemia cells and potential target for highly specific drug delivery. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:66029)
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Abstract
Leukaemia is a blood/bone marrow cancer caused by malignant immature hematopoietic
that has the highest number of lethal outcomes is Acute Myeloid Leukaemia (AML) where
We discovered a fundamental biochemical mechanism in AML cells, which includes ligand
other G-protein coupled receptors, leading to upregulated translation and secretion of the
the mammalian target of rapamycin (mTOR). Tim-3 was observed to participate in galectin-9
activities of cytotoxic lymphoid cells including natural killer (NK) cells and soluble Tim-3
cytotoxic lymphoid cells.
This fundamental pathway provides reliable targets for both highly specific diagnosis and
Furthermore, we demonstrated that the Tim-3/galectin-9 autocrine loop has intracellular
pathway controlled by mTOR.
Item Type: | Thesis (Doctor of Philosophy (PhD)) |
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Thesis advisor: | Sumbayev, Vadim |
Thesis advisor: | Gibbs, Bernhard |
Uncontrolled keywords: | AML, Acute Myeloid leukaemia, Tim-3, Gal-9, Lphn |
Divisions: | Faculties > Sciences > Medway School of Pharmacy |
SWORD Depositor: | System Moodle |
Depositing User: | System Moodle |
Date Deposited: | 15 Feb 2018 10:17 UTC |
Last Modified: | 06 May 2020 03:17 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/66029 (The current URI for this page, for reference purposes) |
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