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Histomorphometry and cortical robusticity of the adult human femur

Miszkiewicz, Justyna J., Mahoney, Patrick (2019) Histomorphometry and cortical robusticity of the adult human femur. Journal of Bone and Mineral Metabolism, 37 . pp. 90-104. ISSN 0914-8779. E-ISSN 1435-5604. (doi:10.1007/s00774-017-0899-3) (KAR id:65580)

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Recent quantitative analyses of human bone microanatomy, as well as theoretical models that propose bone micro- and gross anatomical associations, have started to reveal insights into biological links that may facilitate remodeling processes. However, relationships between bone size and the underlying cortical bone histology remain largely unexplored. The goal of this study is to determine the extent to which static indicators of bone remodeling and vascularity, measured using histomorphometric techniques, relate to femoral midshaft cortical width and robusticity. Using previously published and new quantitative data from 450 adult human male (n = 233) and female (n = 217) femora, we determine if these aspects of femoral size relate to bone microanatomy. Scaling relationships are explored and interpreted within a context of tissue form and function. Analyses revealed that the area and diameter of Haversian canals and secondary osteons, and densities of secondary osteons and osteocyte lacunae from the sub-periosteal region of the posterior midshaft femur cortex were significantly, but not consistently, associated with femoral size. Cortical width and bone robusticity were correlated with osteocyte lacunae density and scaled with positive allometry. Diameter and area of osteons and Haversian canals decreased as the width of cortex and bone robusticity increased, revealing a negative allometric relationship. These results indicate that measures of cortical bone remodeling and vascularity products link to femur size. Allometric relationships between more robust human femora with thicker cortical bone and histological products of bone remodeling correspond with principles of bone functional adaptation. Future studies may benefit from combining bone histomorphometric data with measurements of bone macrostructure.

Item Type: Article
DOI/Identification number: 10.1007/s00774-017-0899-3
Subjects: H Social Sciences
Divisions: Divisions > Division of Human and Social Sciences > School of Anthropology and Conservation
Depositing User: Patrick Mahoney
Date Deposited: 01 Jan 2018 12:54 UTC
Last Modified: 16 Feb 2021 13:52 UTC
Resource URI: (The current URI for this page, for reference purposes)
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