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OC-023?Randomised Trial: The Nutriceutical Zinc Carnosine Works with Bovine Colostrum in Truncating Heavy Exercise Induced Increase in Gut Permeability through Actions on Tight Junctions, Apoptosis and Heat Shock Protein 70 Production

Playford, Raymond J., Davison, Glen, Marchbank, Tania, March, Daniel Scott, Thatcher, Rhys (2016) OC-023?Randomised Trial: The Nutriceutical Zinc Carnosine Works with Bovine Colostrum in Truncating Heavy Exercise Induced Increase in Gut Permeability through Actions on Tight Junctions, Apoptosis and Heat Shock Protein 70 Production. Gut, 65 (S1). A14-A15. ISSN 0017-5749. (doi:10.1136/gutjnl-2016-312388.23) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:65437)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1136/gutjnl-2016-312388.23

Abstract

Introduction Heavy exercise causes gut symptoms and, in extreme cases, “heat stroke” due to increased intestinal permeability of luminal toxins. We examined whether zinc carnosine (ZnC) a health food product taken alone or in combination with bovine colostrum, a natural source of growth factors, moderated such effects.

Results Body temperature increased 20 C and gut permeability (5 h urinary lactulose:rhamnose ratios) increased 3 fold following exercise (0.32 ± 0.016 baseline to 1.0 ± 0.017 at +14 days, p < 0.01). ZnC or colostrum truncated rise by 70% after 14 days treatment. Combination treatment gave additional benefit and truncated exercise induced increase at +2 day (30% reduction, p < 0.01)

Conclusion ZnC taken alone or with colostrum increased epithelial resistance and tight junction structure and may have value for athletes and preventing heat stroke in military personnel.

Item Type: Article
DOI/Identification number: 10.1136/gutjnl-2016-312388.23
Divisions: Divisions > Division of Natural Sciences > School of Sport and Exercise Sciences
Depositing User: Glen Davison
Date Deposited: 14 Dec 2017 00:31 UTC
Last Modified: 16 Feb 2021 13:51 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/65437 (The current URI for this page, for reference purposes)
Davison, Glen: https://orcid.org/0000-0003-4340-0074
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