Skip to main content

Ondansetron fails to attenuate a scopolamineinduced deficit in a Stone maze task

Bratt, Alison M., Kelly, M. Elizabeth, Domeney, Annette M., Naylor, Robert J., Costall, Brenda (1994) Ondansetron fails to attenuate a scopolamineinduced deficit in a Stone maze task. NeuroReport, 5 (15). pp. 1921-1924. ISSN 0959-4965. E-ISSN 1473-558X. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://journals.lww.com/neuroreport/abstract/1994/...

Abstract

THE 5-HT, receptor antagonist ondansetron has previously been reported to improve cognition in the mouse, rat and marmoset in a variety of behavioural paradigms. The present study used the Stone maze to test the effect of ondansetron on the deficit caused by scopolamine in the performance of a highly complex spatial memory task in the rat. Ondansetron administered over a large dose range (1.0 ng kg-1-1.0 mU kg-1, i.p., b.d.) for a period of 10–15 days failed to attenuate the scopolamine deficit. Indeed at one dose level ondansetron (100 ng kg-1, i.p., b.d.) administered in combination with scopolamine (0.5 mg kg-1, i.p.) significantly potentiated the deficit, compared with the performance of rats receiving scopolamine alone.

Item Type: Article
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Alison Bratt
Date Deposited: 07 Dec 2017 10:23 UTC
Last Modified: 29 May 2019 19:59 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/65058 (The current URI for this page, for reference purposes)
  • Depositors only (login required):