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Aged Stone mazeimpaired rats exhibit reduced striatal muscarinic receptor densities

Bratt, Alison M., Kelly, M. Elizabeth, Domeney, Annette M., Naylor, Robert J., Costall, Brenda (1994) Aged Stone mazeimpaired rats exhibit reduced striatal muscarinic receptor densities. NeuroReport, 5 (18). pp. 2678-2682. ISSN 0959-4965. E-ISSN 1473-558X. (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
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Abstract

MUSCARINIC receptor densities, measured by saturation radioligand binding using the muscarinic antagonist [3H]QNB, were compared in the striatum, frontal cortex and hippocampus between two populations of young (3 month) and aged (12–20 month) Hooded Lister rats which had previously been tested in a complex maze task. Aged rats were impaired in their performance of a Stone (14-unit T-maze) task and were less spontaneously active than young rats. Muscarinic receptor numbers were significantly decreased in the striatum of aged rats, whilst numbers in the hippocampus and frontal cortex and receptor affinities in all three areas were unaltered. These results indicate that the age-associated depletion of striatal muscarinic receptors may contribute to deficits in cognitive processing and/or motor behaviour which underlie impairments in the performance of complex spatial tasks.

Item Type: Article
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Alison Bratt
Date Deposited: 07 Dec 2017 10:19 UTC
Last Modified: 29 May 2019 19:59 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/65055 (The current URI for this page, for reference purposes)
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