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Heterogeneity of the hippocampus: effects of subfield lesions on locomotion elicited by dopaminergic agonists

Mittleman, Guy, Bratt, Alison M., Chase, Rachel (1998) Heterogeneity of the hippocampus: effects of subfield lesions on locomotion elicited by dopaminergic agonists. Behavioural Brain Research, 92 (1). 31 - 45. ISSN 0166-4328. (doi:10.1016/S0166-4328(97)00124-1) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
http://dx.doi.org/10.1016/S0166-4328(97)00124-1

Abstract

Abstract Structural abnormalities in the hippocampal formation and overactive dopamine neurotransmission in the ventral striatum are thought to be key pathologies in schizophrenia. This experiment examined the functional contribution of different hippocampal subfields to locomotion elicited by d-amphetamine (0.32-3.2 mg/kg) and the direct agonists quinpirole (0.02-0.5 mg/kg) and SKF 38393 (2.5-15.0 mg/kg). Male rats served as unoperated controls or received one of six different lesions (hippocampal formation, fimbria-fornix, subiculum, CA3-4, entorhinal cortex or dentate gyrus (DG)). The main results indicated that extensive ibotenic acid-induced lesions of the hippocampal formation, or colchicine-induced lesions of the DG enhanced locomotion elicited by the D2 agonist quinpirole. Electrolytic lesions of the fimbria-fornix, in comparison, had much larger effects and resulted in increases in the locomotor response to amphetamine and quinpirole. These results extend previous demonstrations of hippocampal modulation of the ventral striatum by showing that this modulatory influence is dependent on both the location and total extent of cell loss within the hippocampal formation. The results are discussed in relation to the causes of and neurophysiological mechanisms involved in enhanced drug-induced locomotion and in terms of their implications for mental diseases including schizophrenia.

Item Type: Article
DOI/Identification number: 10.1016/S0166-4328(97)00124-1
Uncontrolled keywords: Hippocampus, Fimbria-fornix, Subiculum, CA3-4, Entorhinal cortex, Dentate gyrus, Nucleus accumbens, Ibotenic acid, Kainic acid, Colchicine, Dopamine, D1, D2, -amphetamine, Quinpirole, SKF 38393
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Alison Bratt
Date Deposited: 07 Dec 2017 09:51 UTC
Last Modified: 29 May 2019 19:59 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/65045 (The current URI for this page, for reference purposes)
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