Observing Single Molecules Complexing with Cucurbit[7]uril through Nanogap Surface-Enhanced Raman Spectroscopy

Sigle, Daniel O., Kasera, Setu, Herrmann, Lars O., Palma, Aniello, de Nijs, Bart, Benz, Felix, Mahajan, Sumeet, Baumberg, Jeremy J., Scherman, Oren A. (2016) Observing Single Molecules Complexing with Cucurbit[7]uril through Nanogap Surface-Enhanced Raman Spectroscopy. The Journal of Physical Chemistry Letters, 7 (4). pp. 704-710. ISSN 1948-7185. (doi:10.1021/acs.jpclett.5b02535) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
https://doi.org/10.1021/acs.jpclett.5b02535

Abstract

In recent years, single-molecule sensitivity achievable by surface-enhanced Raman spectroscopy (SERS) has been widely reported. We use this to investigate supramolecular host–guest chemistry with the macrocyclic host cucurbit[7]uril, on a few-to-single-molecule level. A nanogap geometry, comprising individual gold nanoparticles on a planar gold surface spaced by a single layer of molecules, gives intense SERS signals. Plasmonic coupling between the particle and the surface leads to strongly enhanced optical fields in the gap between them, with single-molecule sensitivity established using a modification of the well-known bianalyte method. Changes in the Raman modes of the host molecule are observed when single guests included inside its cavity internally stretch it. Anisotropic intermolecular interactions with the guest are found which show additional distinct features in the Raman modes of the host molecule.

Item Type: Article
DOI/Identification number: 10.1021/acs.jpclett.5b02535
Additional information: This manuscript is in the Cambridge repository. AP does not have access to the AAM.
Subjects: Q Science > QC Physics > QC355 Optics
Q Science > QD Chemistry > QD431 Organic Chemistry- Biochemistry- Proteins, peptides, amino acids
Q Science > QD Chemistry > Analytical Chemistry
Divisions: Faculties > Sciences > School of Physical Sciences
Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Aniello Palma
Date Deposited: 22 Nov 2017 11:22 UTC
Last Modified: 29 May 2019 19:52 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/64611 (The current URI for this page, for reference purposes)
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