Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction

Thompson, Alex J. and Hughes, Michael and Anastasova, Salzitsa and Conklin, Laurie S. and Thomas, Tudor and Leggett, Cadman and Faubion, William A. and Miller, Thomas J. and Delaney, Peter and Lacombe, François and Loiseau, Sacha and Meining, Alexander and Richards-Kortum, Rebecca and Tearney, Guillermo J. and Kelly, Paul and Yang, Guang-Zhong (2017) Position paper: The potential role of optical biopsy in the study and diagnosis of environmental enteric dysfunction. Nature Reviews Gastroenterology & Hepatology, . ISSN 1759-5045. E-ISSN 1759-5053. (doi:https://doi.org/10.1038/nrgastro.2017.147) (Full text available)

Abstract

Environmental enteric dysfunction (EED) is a disease of the small intestine affecting children and adults in low and middle income countries. Arising as a consequence of repeated infections, gut inflammation results in impaired intestinal absorptive and barrier function, leading to poor nutrient uptake and ultimately to stunting and other developmental limitations. Progress towards new biomarkers and interventions for EED is hampered by the practical and ethical difficulties of cross-validation with the gold standard of biopsy and histology. Optical biopsy techniques — which can provide minimally invasive or noninvasive alternatives to biopsy — could offer other routes to validation and could potentially be used as point-of-care tests among the general population. This Consensus Statement identifies and reviews the most promising candidate optical biopsy technologies for applications in EED, critically assesses them against criteria identified for successful deployment in developing world settings, and proposes further lines of enquiry. Importantly, many of the techniques discussed could also be adapted to monitor the impaired intestinal barrier in other settings such as IBD, autoimmune enteropathies, coeliac disease, graft-versus-host disease, small intestinal transplantation or critical care.

Item Type: Article
Subjects: R Medicine
Divisions: Faculties > Sciences > School of Physical Sciences
Faculties > Sciences > School of Physical Sciences > Applied Optics Group
Depositing User: Michael Hughes
Date Deposited: 15 Nov 2017 16:48 UTC
Last Modified: 16 Nov 2017 09:16 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/64454 (The current URI for this page, for reference purposes)
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