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Assay development and efficacy testing of novel and established antimicrobials

Wilson, Ben (2017) Assay development and efficacy testing of novel and established antimicrobials. Master of Science by Research (MScRes) thesis, University of Kent, School of Physical Sciences.

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Abstract

Over the past 25 years, new antimicrobial discovery has ground to a halt, this combined

effective treatments available to humankind decrease.

found them to be inefficient. One of the limiting factors for the discovery of new antimicrobial

by researchers. These methods mainly measure the ability of a compound to diffuse

Within this thesis I developed new testing assays for a family of novel antimicrobials, as

and MIC100 values of all the compounds in the group. They had measurable antimicrobial

Vancomycin, and measurable interaction with Gram-Negative bacteria, coating the cells

I then further explored the coating interaction, adding the compounds to bacteria, but also

efficacy of the established compounds and was also able to overcome resistance

Finally, I developed a modular, 3D printed robot to standardise and increase the accuracy

of the new testing methods.

Item Type: Thesis (Master of Science by Research (MScRes))
Thesis advisor: Mulvihill, Dan
Thesis advisor: Hiscock, Jennifer
Uncontrolled keywords: Biology Biochemistry Microbiology Antimicribials
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
SWORD Depositor: System Moodle
Depositing User: System Moodle
Date Deposited: 13 Nov 2017 10:10 UTC
Last Modified: 15 Nov 2019 00:00 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/64358 (The current URI for this page, for reference purposes)
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