Wilson, Ben (2017) Assay development and efficacy testing of novel and established antimicrobials. Master of Science by Research (MScRes) thesis, University of Kent, School of Physical Sciences. (KAR id:64358)
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Abstract
Over the past 25 years, new antimicrobial discovery has ground to a halt, this combined
effective treatments available to humankind decrease.
found them to be inefficient. One of the limiting factors for the discovery of new antimicrobial
by researchers. These methods mainly measure the ability of a compound to diffuse
Within this thesis I developed new testing assays for a family of novel antimicrobials, as
and MIC100 values of all the compounds in the group. They had measurable antimicrobial
Vancomycin, and measurable interaction with Gram-Negative bacteria, coating the cells
I then further explored the coating interaction, adding the compounds to bacteria, but also
efficacy of the established compounds and was also able to overcome resistance
Finally, I developed a modular, 3D printed robot to standardise and increase the accuracy
of the new testing methods.
Item Type: | Thesis (Master of Science by Research (MScRes)) |
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Thesis advisor: | Mulvihill, Dan |
Thesis advisor: | Hiscock, Jennifer |
Uncontrolled keywords: | Biology Biochemistry Microbiology Antimicribials |
Subjects: | Q Science |
Divisions: | Divisions > Division of Natural Sciences > School of Biosciences |
SWORD Depositor: | System Moodle |
Depositing User: | System Moodle |
Date Deposited: | 13 Nov 2017 10:10 UTC |
Last Modified: | 20 May 2021 13:30 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/64358 (The current URI for this page, for reference purposes) |
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