The input-output relationship approach to structural identifiability analysis

Bearup, Daniel, Evans, N.D., Chappell, M.J. (2012) The input-output relationship approach to structural identifiability analysis. Computer Methods and Programs in Biomedicine, 109 (2). pp. 171-181. ISSN 0169-2607. (doi:10.1016/j.cmpb.2012.10.012)

Abstract

Analysis of the identifiability of a given model system is an essential prerequisite to the determination of model parameters from physical data. However, the tools available for the analysis of non-linear systems can be limited both in applicability and by computational intractability for any but the simplest of models. The input–output relation of a model summarises the input–output structure of the whole system and as such provides the potential for an alternative approach to this analysis. However for this approach to be valid it is necessary to determine whether the monomials of a differential polynomial are linearly independent. A simple test for this property is presented in this work. The derivation and analysis of this relation can be implemented symbolically within Maple. These techniques are applied to analyse classical models from biomedical systems modelling and those of enzyme catalysed reaction schemes.

Item Type: Article
DOI/Identification number: 10.1016/j.cmpb.2012.10.012
Additional information: cited By 7
Uncontrolled keywords: Differential algebra; Computational methods; Identifiability; Enzyme kinetics
Subjects: Q Science > QA Mathematics (inc Computing science)
Q Science > QA Mathematics (inc Computing science) > QA150 Algebra
Q Science > QA Mathematics (inc Computing science) > QA276 Mathematical statistics
Divisions: Faculties > Sciences > School of Mathematics Statistics and Actuarial Science
Faculties > Sciences > School of Mathematics Statistics and Actuarial Science > Applied Mathematics
Depositing User: Daniel Bearup
Date Deposited: 30 Nov 2017 12:14 UTC
Last Modified: 29 May 2019 19:47 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/64321 (The current URI for this page, for reference purposes)
Bearup, Daniel: https://orcid.org/0000-0001-8524-7659
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