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Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation

Mallinson, David, Mullen, Alexander B., Lamprou, Dimitrios A. (2017) Probing polydopamine adhesion to protein and polymer films: microscopic and spectroscopic evaluation. Journal of Materials Science, 53 (5). pp. 3198-3209. ISSN 0022-2461. E-ISSN 1573-4803. (doi:10.1007/s10853-017-1806-y)

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Abstract

Polydopamine has been found to be a biocompatible polymer capable of supporting cell growth and attachment, and to have antibacterial and antifouling properties. Together with its ease of manufacture and application, it ought to make an ideal biomaterial and function well as a coating for implants. In this paper, atomic force microscopy was used to measure the adhesive forces between polymer-, protein- or polydopamine-coated surfaces and a silicon nitride or polydopamine-functionalised probes. Surfaces were further characterised by contact angle goniometry, and solutions by circular dichroism. Polydopamine was further characterised with infrared spectroscopy and Raman spectroscopy. It was found that polydopamine functionalisation of the atomic force microscope probe significantly reduced adhesion to all tested surfaces. For example, adhesion to mica fell from 0.27 ± 0.7 nN nm-1 to 0.05 ± 0.01 nN nm-1. The results suggest that polydopamine coatings are suitable to be used for a variety of biomedical applications.

Item Type: Article
DOI/Identification number: 10.1007/s10853-017-1806-y
Uncontrolled keywords: Polydopamine, Proteins, Atomic force microscopy, Circular dichroism, Adhesion.
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Dimitrios Lamprou
Date Deposited: 08 Nov 2017 14:48 UTC
Last Modified: 29 May 2019 19:46 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/64287 (The current URI for this page, for reference purposes)
Mallinson, David: https://orcid.org/0000-0003-2615-633X
Mullen, Alexander B.: https://orcid.org/0000-0001-7475-5543
Lamprou, Dimitrios A.: https://orcid.org/0000-0002-8740-1661
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