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Tramadol effects on physical performance and sustained attention during a 20-min indoor cycling time-trial: A randomised controlled trial

Holgado, Darias, Zandonai, Thomas, Zabala, Mikel, Hopker, James G., Perakakis, Pandelis, Luque-Casado, Antonio, Ciria, Luis, Guerra-Hernandez, Eduardo, Sanabria, Daniel (2017) Tramadol effects on physical performance and sustained attention during a 20-min indoor cycling time-trial: A randomised controlled trial. Journal of Science and Medicine in Sport, . ISSN 1440-2440. E-ISSN 1878-1861. (doi:10.1016/j.jsams.2017.10.032)

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Objectives: To investigate the effect of tramadol on performance during a 20-min cycling time-trial (Experiment 1), and to test whether sustained attention would be impaired during cycling after tramadol intake (Experiment 2). Design: randomized, double-blind, placebo controlled trial. Methods: In Experiment 1, participants completed a cycling time-trial, 120-min after they ingested either tramadol or placebo. In Experiment 2, participants performed a visual Oddball task during the time-trial. Electroencephalography measures (EEG) were recorded throughout the session. Results: In Experiment 1, average time-trial power output was higher in the tramadol vs. placebo condition (tramadol: 220 watts vs. placebo: 209 watts; p < 0.01). In Experiment 2, no differences between conditions were observed in the average power output (tramadol: 234 watts vs. placebo: 230 watts; p > 0.05). No behavioural differences were found between conditions in the Oddball task. Crucially, the time frequency analysis in Experiment 2 revealed an overall lower target-locked power in the beta-band (p < 0.01), and higher alpha suppression (p < 0.01) in the tramadol vs. placebo condition. At baseline, EEG power spectrum was higher under tramadol than under placebo in Experiment 1 while the reverse was true for Experiment 2. Conclusions: Tramadol improved cycling power output in Experiment 1, but not in Experiment 2, which may be due to the simultaneous performance of a cognitive task. Interestingly enough, the EEG data in Experiment 2 pointed to an impact of tramadol on stimulus processing related to sustained attention. Trial registration: EudraCT number: 2015-005056-96.

Item Type: Article
DOI/Identification number: 10.1016/j.jsams.2017.10.032
Uncontrolled keywords: Doping in sport, Opioid analgesic, Athletes, EEG, Exercise, Brain
Subjects: R Medicine > RC Internal medicine > RC1200 Sports Medicine
R Medicine > RC Internal medicine > RC1235 Physiology of sports
Divisions: Faculties > Sciences > School of Sport and Exercise Sciences
Depositing User: James Hopker
Date Deposited: 10 Nov 2017 16:08 UTC
Last Modified: 29 May 2019 19:45 UTC
Resource URI: (The current URI for this page, for reference purposes)
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