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Does inflammation induced by ultraviolet B and heat rekindling alter pain-related behaviour in rats?

Smith, Melissa, Taylor, Collette, Weerasinghe, Nirosha, Koutsikou, Stella, Lumb, Bridget, Murrell, Jo (2016) Does inflammation induced by ultraviolet B and heat rekindling alter pain-related behaviour in rats? Veterinary Anaesthesia and Analgesia, 43 (5). pp. 579-585. ISSN 1467-2987. E-ISSN 1467-2995. (doi:10.1111/vaa.12349) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:64136)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://doi.org/10.1111/vaa.12349

Abstract

OBJECTIVE: To investigate whether induction of the ultraviolet B and heat rekindling (UVB/HR) model alters burrowing behaviour in rats.

ANIMALS: Sixteen adult male Wistar rats weighing 250-300 g.

RESULTS: Rats in the sham group burrowed means (SD) of 2429 (73) g and 2358 (124) g of sand on days -2 and 3, respectively, while those in the UVB/HR group burrowed 2460 (26) and 2419 (58) g on days -2 and 3, respectively. There was no significant effect of treatment on the amount of sand burrowed at any time point.

CONCLUSIONS AND CLINICAL RELEVANCE: Pain associated with UVB/HR model induction is below the threshold required to affect rat burrowing behaviour and therefore questions the face validity of UVB/HR as a translational model of inflammatory pain.

Item Type: Article
DOI/Identification number: 10.1111/vaa.12349
Subjects: Q Science > QP Physiology (Living systems)
Divisions: Divisions > Division of Natural Sciences > Medway School of Pharmacy
Depositing User: Stella Koutsikou
Date Deposited: 24 Oct 2017 15:13 UTC
Last Modified: 16 Feb 2021 13:49 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/64136 (The current URI for this page, for reference purposes)
Koutsikou, Stella: https://orcid.org/0000-0003-2933-3637
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