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The study of acquired drug resistance in cancer cell lines

Jackson-Soutter, Thomas Harry (2017) The study of acquired drug resistance in cancer cell lines. Master of Science by Research (MScRes) thesis, University of Kent,. (Access to this publication is currently restricted. You may be able to access a copy if URLs are provided)

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Abstract

Cytotoxic drugs are frequently used in the treatment of cancer. However whilst most patients initially respond well to cytotoxic therapies, acquired resistance often develops. In this project we aim to improve understanding of the mechanisms of acquired drug resistance and contribute to the development of a novel assay for determining the potential of different cancer drugs to cause acquired resistance.

This project will lead to a standard protocol for determining the potential of anti-cancer drugs to cause acquired resistance in cancer cells. In this study we have acquired evidence that cultivation of UKF-NB-3 cell line in higher concentrations of docetaxel can result in increased degrees of resistance, possibly depending on the heterogeneity of the cell population. We have additionally characterised the mechanism of resistance through investigation of ATP-binding cassette (ABC) transporters and tubulin expression. With further work, this project will lead to improved understanding of resistance to tubulin binding agents, the cellular pathways responsible and ultimately improved therapeutic strategies and for drug adaptation of cell lines.

Item Type: Thesis (Master of Science by Research (MScRes))
Thesis advisor: Michaelis, Martin
Thesis advisor: Wass, Mark
Uncontrolled keywords: Acquired drug resistance Resistant Cancer cell lines Docetaxel resistance Standard drug adaptation protocol UKF-NB-3 Neuroblastoma ABCB1 P-glycoprotein ABC transporters tubulin binding agents
SWORD Depositor: System Moodle
Depositing User: System Moodle
Date Deposited: 11 Oct 2017 09:10 UTC
Last Modified: 22 Jan 2020 04:10 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/63944 (The current URI for this page, for reference purposes)
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