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Lipid-like Self-Assembling Peptide Nanovesicles for Drug Delivery

Fatouros, Dimitrios G., Lamprou, Dimitrios A., Urquhart, Andrew J., Yannopoulos, Spyros N., Vizirianakis, Ioannis S., Zhang, Shuguang, Koutsopoulos, Sotirios (2014) Lipid-like Self-Assembling Peptide Nanovesicles for Drug Delivery. ACS Applied Materials & Interfaces, 6 (11). pp. 8184-8189. ISSN 1944-8244. (doi:10.1021/am501673x)

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Abstract

Amphiphilic self-assembling peptides are functional materials, which, depending on the amino acid sequence, the peptide length, and the physicochemical conditions, form a variety of nanostructures including nanovesicles, nanotubes, and nanovalves. We designed lipidlike peptides with an aspartic acid or lysine hydrophilic head and a hydrophobic tail composed of six alanines (i.e., ac-A6KCONH2, KA6-CONH2, ac-A6D-COOH, and DA6-COOH). The resulting novel peptides have a length similar to biological lipids and form nanovesicles at physiological conditions. AFM microscopy and light scattering analyses of the positively charged lipid-like ac-A6K-CONH2, KA6-CONH2 peptide formulations showed individual nanovesicles. The negatively charged ac-A6DCOOH and DA6-COOH peptides self-assembled into nanovesicles that formed clusters that upon drying were organized into necklace-like formations of nanovesicles. Encapsulation of probe molecules and release studies through the peptide bilayer suggest that peptide nanovesicles may be good candidates for sustained release of pharmaceutically active hydrophilic and hydrophobic compounds. Lipid-like peptide nanovesicles represent a paradigm shifting system that may complement liposomes for the delivery of diagnostic and therapeutic agents.

Item Type: Article
DOI/Identification number: 10.1021/am501673x
Subjects: R Medicine > RS Pharmacy and materia medica
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Dimitrios Lamprou
Date Deposited: 19 Sep 2017 12:42 UTC
Last Modified: 29 May 2019 19:33 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/63486 (The current URI for this page, for reference purposes)
Lamprou, Dimitrios A.: https://orcid.org/0000-0002-8740-1661
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