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Controlling the melting transition of semi-crystalline self-assembled block copolymer aggregates: controlling release rates of ibuprofen

Monaghan, O. R., Bomans, P. H. H., Sommerdijk, N. A. J. M., Holder, Simon J. (2017) Controlling the melting transition of semi-crystalline self-assembled block copolymer aggregates: controlling release rates of ibuprofen. Polymer Chemistry, 8 (35). pp. 5303-5316. ISSN 1759-9954. E-ISSN 1759-9962. (doi:10.1039/c7py01170a) (KAR id:63387)

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http://dx.doi.org/10.1039/C7PY01170A

Abstract

Bicontinuous nanospheres and multi-lamellar micelles were self-assembled from poly[ethylene oxide]-block-(poly[octadecyl methacrylate]-random-poly[docosyl methacrylate]), (PEO-b-[PODMA-co-PDSMA]) where PEO is the hydrophilic block (25 wt%) and PODMA/PDSMA is the semi-crystalline hydrophobic block (75 wt%) that gives a thermoresponsive component to the self-assembled aggregates. By varying the relative molar proportion of DSMA to ODMA (from 0 : 1 to 1 : 0) in the synthesis of the copolymers by atom transfer radical polymerisation, the melting transition Tm of the hydrophobic block could be varied from 21.5 to 41.1 °C in the solid state. When self-assembled in aqueous dispersions the Tm range was 23.4 to 41.3 °C, closely matching that of the solid samples. Preliminary analysis of the rate of release of ibuprofen from three of the block copolymer aggregates demonstrated that the rate of release was correlated with the degree of crystallinity of the hydrophobic block and that increasing temperature causes melting and a significantly enhanced release rate.

Item Type: Article
DOI/Identification number: 10.1039/c7py01170a
Subjects: Q Science > QD Chemistry > QD473 Physical properties in relation to structure
Divisions: Faculties > Sciences > School of Physical Sciences > Functional Materials Group
Depositing User: Simon Holder
Date Deposited: 12 Sep 2017 16:30 UTC
Last Modified: 12 Jul 2019 14:10 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/63387 (The current URI for this page, for reference purposes)
Holder, Simon J.: https://orcid.org/0000-0001-8977-9257
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