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Novel Gemcitabine Conjugated Albumin Nanoparticles: a Potential Strategy to Enhance Drug Efficacy in Pancreatic Cancer Treatment

Kushwah, Varun, Agrawal, Ashish Kumar, Dora, Chander Parkash, Mallinson, David, Lamprou, Dimitrios A., Gupta, Ramesh C., Jain, Sanyog (2017) Novel Gemcitabine Conjugated Albumin Nanoparticles: a Potential Strategy to Enhance Drug Efficacy in Pancreatic Cancer Treatment. Pharmaceutical Research, . pp. 1-17. ISSN 0724-8741. E-ISSN 1573-904X. (doi:10.1007/s11095-017-2238-8) (KAR id:62653)

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https://dx.doi.org/10.1007/s11095-017-2238-8

Abstract

Purpose

The synthesized GEM-BSA conjugate was extensively characterized by NMR, FTIR, MALDI-TOF and elemental analysis. Conjugation mediated changes in structural conformation and physicochemical properties were analysed by fluorescence, Raman and CD spectroscopy, DSC and contact angle analysis. Further, BSA nanoparticles were developed from BSA-GEM conjugate and extensively evaluated against in-vitro pancreatic cancer cell lines to explore cellular uptake pathways and therapeutic efficacy.

Results

GEM-BSA NPs were found to potentiate the therapeutic efficacy by altering physicochemical properties, improving cellular uptake and stability of GEM and thus demonstrated promising therapeutic potential over free drug.

Item Type: Article
DOI/Identification number: 10.1007/s11095-017-2238-8
Uncontrolled keywords: BSA nanoparticles, conjugate, gemcitabine, MIA PaCa-2, PANC-1
Divisions: Faculties > Sciences > Medway School of Pharmacy
Depositing User: Dimitrios Lamprou
Date Deposited: 14 Aug 2017 07:50 UTC
Last Modified: 01 Aug 2019 10:42 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/62653 (The current URI for this page, for reference purposes)
Lamprou, Dimitrios A.: https://orcid.org/0000-0002-8740-1661
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