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The use of a self-paced cardiopulmonary exercise test in the pre and post-operative care of patients with cardiovascular disease

Jenkins, Lauren A. (2017) The use of a self-paced cardiopulmonary exercise test in the pre and post-operative care of patients with cardiovascular disease. Doctor of Philosophy (PhD) thesis, University of Kent,. (KAR id:62551)

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Abstract

The aim of this thesis was to assess the ability of a self-paced (SPV) cardiopulmonary exercise test (CPET) in assessing patient fitness prior to elective surgery, and its ability to predict postoperative outcomes. The SPV is a 10 minute test which is comprised of 5 × 2 minute stages. Each stage is fixed to a level on the ratings of perceived exertion (RPE) scale, in an incremental format (RPE: 11, 13, 15, 17 and 20). This test eliminates the need of practitioners having to choose the most appropriate work rate increments to ensure a patient reaches volitional exhaustion within the recommended time period (8-12 min).

Study 2 investigated the physiological responses between the SPV and a standard CPET (sCPET) protocol between a young (18-30 years) and a middle aged to older adult (50-75 years) population. This was in the attempt to gain an understanding of the response to the protocol and whether these responses differ with age. Expired gases, Q, SV, muscular deoxyhaemoglobin (deoxyHb) and electromyography (EMG) at the vastus lateralis were recorded throughout both tests. Results demonstrated a significantly higher V?O2max in the SPV (49.68 ± 10.26 ml·kg-1·min-1) vs. a sCPET (47.70 ± 9.98 ml·kg-1·min-1) in the young, but no differences in the middle aged to older adult group (> 0.05). Q and SV were significantly higher in the SPV vs. a sCPET in the young (< 0.05) but no differences in the middle aged to older adult group (> 0.05). No differences were seen in both age groups in the deoxyHb and EMG response (> 0.05). Findings from this study suggest that in the young group, the SPV produces higher V?O2max values as a result of an increase in oxygen delivery (enhanced Q). However, likely due to age-related differences, particularly in the cardiovascular response to exercise, the middle aged to older adult group achieved similar V?O2max values regardless of them reaching a higher physiological workload.

Study 4 aimed to determine if the SPV can assess patient's preoperative risk similar to sCPET and if exercise variables obtained from the test can accurately predict post-operative outcome. Fifty patients with cardiovascular related co-morbidities completed one sCPET and one SPV, although only thirty of those patients when ahead with surgery. Post-surgery, patients were monitored for incidence of morbidity on postoperative days 3 and 5, length of hospital stay, and incidence of mortality in the 30 days after surgery. Patients achieved a significantly higher V?O2peak, HR, V?E, peak PO and TTE in the SPV compared to the sCPET (P < 0.05). Logistic regression analysis demonstrated that for the thirty patients who had surgery, none of the CPET variables were associated with postoperative morbidity at either day 3 or 5 (P > 0.05). Although when combining postoperative morbidity at days 3 and 5, logistic regression analysis showed that oxygen pulse at AT obtained from the SPV was significantly related to postoperative complications (P < 0.05). ROC curve analysis demonstrated oxygen pulse at AT to provide an AUC of 0.72 a.u. (95%CI 0.51 to 0.92), with an optimal cut-off point of 8.5 ml/beat-1 which provided 72.7% sensitivity and 71.4% specificity. It was concluded that the SPV was able to assess preoperative fitness comparable to the sCPET. Although none of the CPET variable from either test were associated with postoperative morbidity, which is likely a result of the small sample size.

The conclusion for this thesis is that a self-paced CPET test is able to reliably assess cardiovascular patient's fitness comparable to traditional methods. This type of test may be seen as advantageous, this is because the SPV takes away the need of clinicians having to choose the most appropriate work rate increments, it allows patients to have full control over the test, and it ensures that regardless of fitness all patients will be exercise for the recommended test time. The fixed test duration of 10 minutes may also help to improve the efficiency of running busy CPET clinics. There are clear benefits to using the SPV, although further research is required first to assess its ability of predicting postoperative outcome in a much larger sample, and to determine if it can be used to the same advantages sCPET protocols have previously demonstrated.

Item Type: Thesis (Doctor of Philosophy (PhD))
Thesis advisor: Hopker, James
Thesis advisor: Mauger, Lex
Uncontrolled keywords: Exercise Physiology Sports Medicine Clinical Exercise Testing Surgery
Divisions: Divisions > Division of Natural Sciences > School of Sport and Exercise Sciences
SWORD Depositor: System Moodle
Depositing User: System Moodle
Date Deposited: 03 Aug 2017 15:11 UTC
Last Modified: 16 Feb 2021 13:47 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/62551 (The current URI for this page, for reference purposes)
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