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CO2 sensing in fungi: at the heart of metabolic signaling

Martin, Ronny, Pohlers, Susann, Mühlschlegel, Fritz A., Kurzai, Oliver (2017) CO2 sensing in fungi: at the heart of metabolic signaling. Current Genetics, . ISSN 0172-8083. E-ISSN 1432-0983. (doi:10.1007/s00294-017-0700-0) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided) (KAR id:62388)

The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided. (Contact us about this Publication)
Official URL
https://dx.doi.org/10.1007/s00294-017-0700-0

Abstract

Adaptation to the changing environmental CO2 levels is essential for all living cells. In particular, microorganisms colonizing and infecting the human body are exposed to highly variable concentrations, ranging from atmospheric 0.04 to 5% and more in blood and specific host niches. Carbonic anhydrases are highly conserved metalloenzymes that enable fixation of CO2 by its conversion into bicarbonate. This process is not only crucial to ensure the supply of adequate carbon amounts for cellular metabolism, but also contributes to several signaling processes in fungi, including morphology and communication. The fungal specific carbonic anhydrase gene NCE103 is transcribed in response to CO2 availability. As recently shown, this regulation relies on the ATF/CREB transcription factor Cst6 and the AGC family protein kinase Sch9. Here, we review the regulatory mechanisms which control NCE103 expression in the model organism Saccharomyces cerevisiae and the pathogenic yeasts Candida albicans and Candida glabrata and discuss which additional factors might contribute in this novel CO2 sensing cascade.

Item Type: Article
DOI/Identification number: 10.1007/s00294-017-0700-0
Uncontrolled keywords: Fungi, CO2, Adaptation, Carbonic anhydrase
Subjects: Q Science
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 25 Jul 2017 14:31 UTC
Last Modified: 29 May 2019 19:14 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/62388 (The current URI for this page, for reference purposes)
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