Gumbs, Tamrin L., White, Lisa J., Wells, Neil J., Shepherd, Helena J., Hiscock, Jennifer R. (2018) 'Frustrated' hydrogen bonded self-associated systems as templates towards DNA incorporated nanostructure formation. Supramolecular Chemistry, 30 . pp. 42-51. ISSN 1061-0278. E-ISSN 1029-0478. (doi:10.1080/10610278.2017.1351613) (KAR id:62248)
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Official URL http://dx.doi.org/10.1080/10610278.2017.1351613 |
Abstract
Herein, we present the synthesis of a thymine nucleobase appended ‘frustrated’ monomer, which exhibits self-association in DMSO solutions through the formation of hydrogen bonds. This self-association process has been explored in both competitive DMSO solutions and the solid state, using a combination of NMR and single crystal X-ray diffraction techniques. The self-associative equilibria within the solution state are balanced in such a way that the hydrogen bond donating (HBD) and accepting (HBA) thymine residue present within the monomeric structure is free to coordinate further guest species such as the complimentary DNA base adenine. The adenine simulants, 2-aminopyridine and 2,6-diaminopyridine have been used to explore the potential of these self-associated structures towards the coordination of complimentary DNA base pairs.
Item Type: | Article |
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DOI/Identification number: | 10.1080/10610278.2017.1351613 |
Uncontrolled keywords: | self-association; hydrogen bonding; host-guest chemistry |
Divisions: | Divisions > Division of Natural Sciences > School of Physical Sciences |
Depositing User: | Jennifer Hiscock |
Date Deposited: | 11 Jul 2017 09:57 UTC |
Last Modified: | 16 Feb 2021 13:46 UTC |
Resource URI: | https://kar.kent.ac.uk/id/eprint/62248 (The current URI for this page, for reference purposes) |
Shepherd, Helena J.: | ![]() |
Hiscock, Jennifer R.: | ![]() |
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