Skip to main content

Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line

Raasakka, Arne, Ruskamo, Salla, Kowal, Julia, Barker, Robert, Baumann, Anne, Martel, Anne, Tuusa, Jussi, Myllykoski, Matti, Bürck, Jochen, Ulrich, Anne S., and others. (2017) Membrane Association Landscape of Myelin Basic Protein Portrays Formation of the Myelin Major Dense Line. Scientific reports, 7 (1). Article Number 4974. ISSN 2045-2322. (doi:10.1038/s41598-017-05364-3) (KAR id:62247)

PDF Publisher pdf
Language: English


Creative Commons Licence
This work is licensed under a Creative Commons Attribution 4.0 International License.
Download (1MB) Preview
Official URL
https://doi.org/10.1038/s41598-017-05364-3

Abstract

Compact myelin comprises most of the dry weight of myelin, and its insulative nature is the basis for saltatory conduction of nerve impulses. The major dense line (MDL) is a 3-nm compartment between

sclerosis. The association of MBP with lipid membranes has been studied for decades, but the MBPdriven formation of the MDL remains elusive at the biomolecular level. We employed complementary

single membrane leaflet to the organisation of a stable MDL. Our results support the formation of an amorphous protein phase of MBP between two membrane bilayers and provide a molecular model for

MDL formation during myelination, which is of importance when understanding myelin assembly and demyelinating conditions.

Item Type: Article
DOI/Identification number: 10.1038/s41598-017-05364-3
Divisions: Faculties > Sciences > School of Physical Sciences
Depositing User: Robert Barker
Date Deposited: 11 Jul 2017 09:40 UTC
Last Modified: 22 Sep 2020 16:24 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/62247 (The current URI for this page, for reference purposes)
Barker, Robert: https://orcid.org/0000-0002-8645-5385
  • Depositors only (login required):