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Preterm infants have significantly longer telomeres than their term born counterparts

Saretzki, Gabriele, Vasu, Vimal, Turner, Kara Jane, George, Shermi, Greenall, John, Slijepcevic, Predrag, Griffin, Darren K. (2017) Preterm infants have significantly longer telomeres than their term born counterparts. PLOS ONE, 12 (6). e0180082. ISSN 1932-6203. (doi:10.1371/journal.pone.0180082) (KAR id:62217)

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Abstract

There are well-established morbidities associated with preterm birth including respiratory, neurocognitive and developmental disorders. However several others have recently emerged

shows that these morbidities persist into adult life, posing a significant public health concern. In this study, we measured relative telomere length in leukocytes as an indicator of biological

hypothesis that by term equivalent age, preterm infants have significantly shorter telomeres (thus suggesting that they are prematurely aged). Our results demonstrate that relative telomere

preterm infants who had telomere length measurements available at both birth and term age (n = 5) suggests that telomere attrition rate is negatively correlated with increasing gestational

in the preterm at birth group. In addition, telomere lengths were not significantly different between preterm infants sampled at birth and those sampled at term equivalent age. These

telomere attrition rate increases.

Item Type: Article
DOI/Identification number: 10.1371/journal.pone.0180082
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Sue Davies
Date Deposited: 05 Jul 2017 09:32 UTC
Last Modified: 23 Jan 2020 04:13 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/62217 (The current URI for this page, for reference purposes)
Griffin, Darren K.: https://orcid.org/0000-0001-7595-3226
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