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Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil

Wichner, Dominik, Idris, Hamidah, Houssen, Wael E, McEwan, Andrew R, Bull, Alan T., Asenjo, Juan A, Goodfellow, Michael, Jaspars, Marcel, Ebel, Rainer, Rateb, Mostafa E and others. (2016) Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil. The Journal of Antibiotics, 70 (4). pp. 448-453. ISSN 0021-8820. (doi:10.1038/ja.2016.78) (KAR id:61946)

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Abstract

The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A–F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1–6 displayed moderate inhibitory activity against HIV integrase.

Item Type: Article
DOI/Identification number: 10.1038/ja.2016.78
Subjects: Q Science
Divisions: Divisions > Division of Natural Sciences > School of Biosciences
Depositing User: Susan Davies
Date Deposited: 05 Jun 2017 10:32 UTC
Last Modified: 29 Aug 2019 13:59 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/61946 (The current URI for this page, for reference purposes)
Bull, Alan T.: https://orcid.org/0000-0001-6223-7722
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