Wichner, Dominik, Idris, Hamidah, Houssen, Wael E, McEwan, Andrew R, Bull, Alan T., Asenjo, Juan A, Goodfellow, Michael, Jaspars, Marcel, Ebel, Rainer, Rateb, Mostafa E and others. (2016) Isolation and anti-HIV-1 integrase activity of lentzeosides A–F from extremotolerant lentzea sp. H45, a strain isolated from a high-altitude Atacama Desert soil. The Journal of Antibiotics, 70 (4). pp. 448-453. ISSN 0021-8820. (doi:10.1038/ja.2016.78) (KAR id:61946)
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| Official URL: https://doi.org/10.1038/ja.2016.78 |
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Abstract
The extremotolerant isolate H45 was one of several actinomycetes isolated from a high-altitude Atacama Desert soil collected in northwest Chile. The isolate was identified as a new Lentzea sp. using a combination of chemotaxonomic, morphological and phylogenetic properties. Large scale fermentation of the strain in two different media followed by chromatographic purification led to the isolation of six new diene and monoene glycosides named lentzeosides A–F, together with the known compound (Z)-3-hexenyl glucoside. The structures of the new compounds were confirmed by HRESIMS and NMR analyses. Compounds 1–6 displayed moderate inhibitory activity against HIV integrase.
| Item Type: | Article |
|---|---|
| DOI/Identification number: | 10.1038/ja.2016.78 |
| Subjects: | Q Science |
| Divisions: | Divisions > Division of Natural Sciences > Biosciences |
| Depositing User: | Susan Davies |
| Date Deposited: | 05 Jun 2017 10:32 UTC |
| Last Modified: | 29 Aug 2019 13:59 UTC |
| Resource URI: | https://kar.kent.ac.uk/id/eprint/61946 (The current URI for this page, for reference purposes) |
| Bull, Alan T.: |  https://orcid.org/0000-0001-6223-7722 |
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