Malignant astrocytic glioma: genetics, biology, and paths to treatment.

Furnari, FB, Fenton, TR, Bachoo, RM, Mukasa, A, Stommel, JM, Stegh, A, Hahn, WC, Ligon, KL, Louis, DN, Brennan, C, and others. (2007) Malignant astrocytic glioma: genetics, biology, and paths to treatment. Genes Dev, 21 (21). pp. 2683-2710. (doi:10.1101/gad.1596707) (KAR id:61523)

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Official URL: http://dx.doi.org/10.1101/gad.1596707

Abstract

Malignant astrocytic gliomas such as glioblastoma are the most common and lethal intracranial tumors. These cancers exhibit a relentless malignant progression characterized by widespread invasion throughout the brain, resistance to traditional and newer targeted therapeutic approaches, destruction of normal brain tissue, and certain death. The recent confluence of advances in stem cell biology, cell signaling, genome and computational science and genetic model systems have revolutionized our understanding of the mechanisms underlying the genetics, biology and clinical behavior of glioblastoma. This progress is fueling new opportunities for understanding the fundamental basis for development of this devastating disease and also novel therapies that, for the first time, portend meaningful clinical responses.

Item Type:	Article
DOI/Identification number:	10.1101/gad.1596707
Uncontrolled keywords:	Animals, Animals, Genetically Modified, Antineoplastic Combined Chemotherapy Protocols, Astrocytoma, Brain Neoplasms, Disease Models, Animal, Gene Regulatory Networks, Humans, Models, Biological, Necrosis, Neoplasm Invasiveness, Neoplasm Staging, Neovascularization, Pathologic
Divisions:	Divisions > Division of Natural Sciences > Biosciences
Depositing User:	Tim Fenton
Date Deposited:	19 Dec 2018 06:19 UTC
Last Modified:	16 Nov 2021 10:24 UTC
Resource URI:	https://kar.kent.ac.uk/id/eprint/61523 (The current URI for this page, for reference purposes)

University of Kent Author Information

Fenton, TR.

Creator's ORCID:	https://orcid.org/0000-0002-4737-8233
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