Functions and regulation of the 70 kDa ribosomal S6 kinases

Fenton, TR and Gout, IT (2010) Functions and regulation of the 70 kDa ribosomal S6 kinases. International Journal of Biochemistry and Cell Biology, 43 (1). pp. 47-59. ISSN 1357-2725. E-ISSN 1878-5875. (doi:https://doi.org/10.1016/j.biocel.2010.09.018) (The full text of this publication is not currently available from this repository. You may be able to access a copy if URLs are provided)

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Official URL
http://dx.doi.org/10.1016/j.biocel.2010.09.018

Abstract

The 70 kDa ribosomal protein S6 kinases, S6K1 and S6K2 are two highly homologous serine/threonine kinases that are activated in response to growth factors, cytokines and nutrients. The S6 kinases have been linked to diverse cellular processes, including protein synthesis, mRNA processing, glucose homeostasis, cell growth and survival. Studies in model organisms have highlighted the roles that S6K activity plays in a number of pathologies, including obesity, diabetes, ageing and cancer. The importance of S6K function in human diseases has led to the development of S6K-specific inhibitors by a number of companies, offering the promise of improved tools with which to study these enzymes and potentially the effective targeting of deregulated S6K signalling in patients. Here we review the current literature on the role of S6Ks in the regulation of cell growth, survival and proliferation downstream of various signalling pathways and how their dysregulation contributes to the pathogenesis of human diseases.

Item Type: Article
Uncontrolled keywords: Science & Technology, Life Sciences & Biomedicine, Biochemistry & Molecular Biology, Cell Biology, BIOCHEMISTRY & MOLECULAR BIOLOGY, CELL BIOLOGY, S6 kinase, Signalling pathways, Translation, Cell growth and survival, Cancer and ageing, INSULIN-RECEPTOR SUBSTRATE-1, MOUSE 3T3 FIBROBLASTS, CAP-BINDING COMPLEX, PROTEIN-KINASE, MAMMALIAN TARGET, CELL-GROWTH, IN-VIVO, PHOSPHORYLATION SITES, LIFE-SPAN, SIGNAL-TRANSDUCTION
Divisions: Faculties > Sciences > School of Biosciences
Depositing User: Tim Fenton
Date Deposited: 23 May 2017 16:50 UTC
Last Modified: 24 May 2017 09:32 UTC
Resource URI: https://kar.kent.ac.uk/id/eprint/61517 (The current URI for this page, for reference purposes)
Fenton, TR: https://orcid.org/0000-0002-4737-8233
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